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- W2024144883 abstract "RATIONALE: Specific Immunotherapy (SIT) is the only known treatment for allergic disease that modulates the immune response causing the disease. The current study was designed to investigate several changes in cellular parameters during SIT treatment previously described in separate studies. METHODS: PBMC from 6 SIT treated and 6 untreated grass allergic patients as well as 8 controls were stimulated directly after isolation or after a subsequent depletion of CD25+. The effect of regulatory cytokines in the cell cultures were investigated by blocking with anti-IL-10 receptor and anti-TGF-beta antibodies. Proliferation, cytokines, intracellular cytokines and surface markers were measured after 6 days of incubation with medium, purified grass allergens, grass extract or tetanous toxoid (TT). Surface markers were also measured on purified PBMC. Histamine release and basophil activation markers were measured on whole blood after stimulation with medium or grass extract for 1 hour. RESULTS: SIT treated patients produced significantly more IL-10 compared to the other groups when stimulated with grass allergens but not TT. Neutralisation of regulatory cytokines induced a significant increase in allergen-induced IL-5 production only in the SIT group. No changes in proliferation, surface markers or intracellular cytokine levels were observed. All basophil activation parameters are reduced after treatment with SIT compared to the untreated group. CONCLUSIONS: SIT induces a significant increase in IL-10 production and the increase in IL-5 production after neutralisation of regulatory cytokines indicates a modulated T-cell response after immunotherapy. The immediate response from basophils is reduced as a consequence of SIT." @default.
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- W2024144883 date "2006-02-01" @default.
- W2024144883 modified "2023-09-26" @default.
- W2024144883 title "Screening for Cellular Changes During Grass-Specific Subcutaneous Immunotherapy" @default.
- W2024144883 doi "https://doi.org/10.1016/j.jaci.2005.12.1042" @default.
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