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- W2024146750 abstract "To the Editor:I read with interest the article by Alderman et al1 on the clinical significance of hypokalemia and hyperkalemia in the antihypertensive treatment and prevention of cardiovascular complications. The conclusion was that, in most patients, concerns about potassium levels should not influence the clinician's decision about initiating hypertension treatment with low-moderate doses of thiazides. Chlorthalidone reduces the risk of congestive heart failure, in comparison with lisinopril and amlodipine,1 but it also activates the renin-angiotensin-aldosterone system. We address the issue that, beyond plasma potassium levels, during thiazides, the activation of the renin-angiotensin-aldosterone system and, in particular, the stimulation of mineralocorticoid receptors (MRs) are key determinants in the inflammatory process and the progression of …" @default.
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- W2024146750 date "2012-08-01" @default.
- W2024146750 modified "2023-10-18" @default.
- W2024146750 title "Serum Potassium, Thiazides, Aldosterone, and Mineralocorticoid Receptors" @default.
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- W2024146750 doi "https://doi.org/10.1161/hypertensionaha.112.197889" @default.
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