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• W2024147079 startingPage "1460" @default.
• W2024147079 abstract "Immunization with attenuated Plasmodium sporozoites or viral vectored vaccines can induce protective CD8(+) T cells that can find and eliminate liver-stage malaria parasites. A key question is whether CD8(+) T cells must recognize and eliminate each parasite in the liver or whether bystander killing can occur. To test this, we transferred antigen-specific effector CD8(+) T cells to mice that were then coinfected with two Plasmodium berghei strains, only one of which could be recognized directly by the transferred T cells. We found that the noncognate parasites developed normally in these mice, demonstrating that bystander killing of parasites does not occur during the CD8(+) T cell response to malaria parasites. Rather, elimination of infected parasites is likely mediated by direct recognition of infected hepatocytes by antigen-specific CD8(+) T cells." @default.
• W2024147079 created "2016-06-24" @default.
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• W2024147079 date "2014-04-01" @default.
• W2024147079 modified "2023-10-14" @default.
• W2024147079 title "CD8 ⁺ T Cells Eliminate Liver-Stage Plasmodium berghei Parasites without Detectable Bystander Effect" @default.
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• W2024147079 doi "https://doi.org/10.1128/iai.01500-13" @default.
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