Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024147150> ?p ?o ?g. }
- W2024147150 abstract "Transcriptional silencing of subtelomeric genes is associated with telomere length, which is correlated with age. Long and short telomeres in young and old people, respectively, coincide with gene repression and activation in each case. In addition, differential location of genes with respect to telomeres causes telomere position effect. There is very little evidence of the manner in which age-related telomere length affects the expression of specific human subtelomeric genes. We analyzed the relationship between telomere length and gene expression levels in fibroblasts derived from human donors at ages ranging from 0-70 years. We studied three groups of genes located between 100 and 150 kb, 200 and 250 kb, and > 300 kb away from telomeres. We found that the chromatin modifier-encoding genes Eu-HMTase1, ZMYND11, and RASA3 were overexpressed in adults. Our results suggest that short telomere length-related overexpression of chromatin modifiers could underlie transcriptional changes contributing to cellular senescence." @default.
- W2024147150 created "2016-06-24" @default.
- W2024147150 creator A5009466489 @default.
- W2024147150 creator A5015341504 @default.
- W2024147150 creator A5040988514 @default.
- W2024147150 creator A5058112481 @default.
- W2024147150 date "2009-11-30" @default.
- W2024147150 modified "2023-10-17" @default.
- W2024147150 title "Role of telomere length in subtelomeric gene expression and its possible relation to cellular senescence" @default.
- W2024147150 cites W1541877559 @default.
- W2024147150 cites W1970657278 @default.
- W2024147150 cites W2011779395 @default.
- W2024147150 cites W2013078522 @default.
- W2024147150 cites W2020606280 @default.
- W2024147150 cites W2022957238 @default.
- W2024147150 cites W2023370144 @default.
- W2024147150 cites W2032407757 @default.
- W2024147150 cites W2043781485 @default.
- W2024147150 cites W2069156698 @default.
- W2024147150 cites W2075202222 @default.
- W2024147150 cites W2090189277 @default.
- W2024147150 cites W2090325890 @default.
- W2024147150 cites W2104908670 @default.
- W2024147150 cites W2122093215 @default.
- W2024147150 cites W2126815966 @default.
- W2024147150 cites W2142617031 @default.
- W2024147150 cites W2150788604 @default.
- W2024147150 cites W2163550224 @default.
- W2024147150 cites W2163771097 @default.
- W2024147150 cites W2175722093 @default.
- W2024147150 cites W2315355727 @default.
- W2024147150 cites W2324248025 @default.
- W2024147150 cites W2530138066 @default.
- W2024147150 doi "https://doi.org/10.5483/bmbrep.2009.42.11.747" @default.
- W2024147150 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19944017" @default.
- W2024147150 hasPublicationYear "2009" @default.
- W2024147150 type Work @default.
- W2024147150 sameAs 2024147150 @default.
- W2024147150 citedByCount "10" @default.
- W2024147150 countsByYear W20241471502012 @default.
- W2024147150 countsByYear W20241471502015 @default.
- W2024147150 countsByYear W20241471502016 @default.
- W2024147150 countsByYear W20241471502021 @default.
- W2024147150 crossrefType "journal-article" @default.
- W2024147150 hasAuthorship W2024147150A5009466489 @default.
- W2024147150 hasAuthorship W2024147150A5015341504 @default.
- W2024147150 hasAuthorship W2024147150A5040988514 @default.
- W2024147150 hasAuthorship W2024147150A5058112481 @default.
- W2024147150 hasBestOaLocation W20241471501 @default.
- W2024147150 hasConcept C104317684 @default.
- W2024147150 hasConcept C119056186 @default.
- W2024147150 hasConcept C150194340 @default.
- W2024147150 hasConcept C153911025 @default.
- W2024147150 hasConcept C165864922 @default.
- W2024147150 hasConcept C177336024 @default.
- W2024147150 hasConcept C202265312 @default.
- W2024147150 hasConcept C23069440 @default.
- W2024147150 hasConcept C522857546 @default.
- W2024147150 hasConcept C54355233 @default.
- W2024147150 hasConcept C83640560 @default.
- W2024147150 hasConcept C86339819 @default.
- W2024147150 hasConcept C86803240 @default.
- W2024147150 hasConcept C94966510 @default.
- W2024147150 hasConcept C95444343 @default.
- W2024147150 hasConceptScore W2024147150C104317684 @default.
- W2024147150 hasConceptScore W2024147150C119056186 @default.
- W2024147150 hasConceptScore W2024147150C150194340 @default.
- W2024147150 hasConceptScore W2024147150C153911025 @default.
- W2024147150 hasConceptScore W2024147150C165864922 @default.
- W2024147150 hasConceptScore W2024147150C177336024 @default.
- W2024147150 hasConceptScore W2024147150C202265312 @default.
- W2024147150 hasConceptScore W2024147150C23069440 @default.
- W2024147150 hasConceptScore W2024147150C522857546 @default.
- W2024147150 hasConceptScore W2024147150C54355233 @default.
- W2024147150 hasConceptScore W2024147150C83640560 @default.
- W2024147150 hasConceptScore W2024147150C86339819 @default.
- W2024147150 hasConceptScore W2024147150C86803240 @default.
- W2024147150 hasConceptScore W2024147150C94966510 @default.
- W2024147150 hasConceptScore W2024147150C95444343 @default.
- W2024147150 hasLocation W20241471501 @default.
- W2024147150 hasLocation W20241471502 @default.
- W2024147150 hasOpenAccess W2024147150 @default.
- W2024147150 hasPrimaryLocation W20241471501 @default.
- W2024147150 hasRelatedWork W1585380636 @default.
- W2024147150 hasRelatedWork W1978671317 @default.
- W2024147150 hasRelatedWork W1997316701 @default.
- W2024147150 hasRelatedWork W2004733200 @default.
- W2024147150 hasRelatedWork W2014699214 @default.
- W2024147150 hasRelatedWork W2022653829 @default.
- W2024147150 hasRelatedWork W2070587656 @default.
- W2024147150 hasRelatedWork W2078860873 @default.
- W2024147150 hasRelatedWork W2084850697 @default.
- W2024147150 hasRelatedWork W2095696971 @default.
- W2024147150 hasRelatedWork W2122093215 @default.
- W2024147150 hasRelatedWork W2122103654 @default.
- W2024147150 hasRelatedWork W2134291868 @default.
- W2024147150 hasRelatedWork W2139989755 @default.
- W2024147150 hasRelatedWork W2164990645 @default.
- W2024147150 hasRelatedWork W2745108268 @default.
- W2024147150 hasRelatedWork W2908714463 @default.