Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024147785> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W2024147785 abstract "Abstract Cardiac scintigraphic studies using [ 123 I]MIBG have demonstrated a heterogeneous myocardial accumulation of radioactivity in diabetes. Recently, we have shown that this accumulation of MIBG was correlated with a heterogeneous decrease in the level of norepinephrine transporter (NET). In diabetes, an aldose reductase (AR) is activated in the peripheral nerve tissue, and the sorbitol that accumulates causes nerve dysfunction and degeneration. Therefore, to assess the influence of AR on the reduction in NET, we investigated changes in the myocardial expression of NET and distribution of [ 12 5 I]MIBG in a streptozotocin (STZ)-induced animal model of diabetes, the STZ rats, treated with AR inhibitor (ARI). NET expression levels were investigated and were lower in the inferior wall than anterior wall in STZ rats. On the other hand, there was no significant difference between the anterior and inferior walls in control or ARI rats. Regarding the distribution of [ 125 I]MIBG, in STZ rats, there was significantly less uptake in the inferior than anterior wall. Conversely, there was no significant difference between the anterior and inferior walls in ARI and control rats. In conclusion, ARI suppressed the regional reduction of NET expression in diabetic rats, and this suppression prevented the heterogeneous accumulation of MIBG." @default.
- W2024147785 created "2016-06-24" @default.
- W2024147785 creator A5007883181 @default.
- W2024147785 creator A5020616386 @default.
- W2024147785 creator A5033938344 @default.
- W2024147785 creator A5088981771 @default.
- W2024147785 creator A5091529335 @default.
- W2024147785 date "2004-03-01" @default.
- W2024147785 modified "2023-09-24" @default.
- W2024147785 title "The effect of aldose reductase inhibitor on heterogeneous MIBG accumulation in diabetes; implication for norepinephrine transporter expression" @default.
- W2024147785 cites W1853806315 @default.
- W2024147785 cites W2012373895 @default.
- W2024147785 cites W2016038913 @default.
- W2024147785 cites W2052306524 @default.
- W2024147785 cites W2068504431 @default.
- W2024147785 cites W2083873180 @default.
- W2024147785 cites W2101884603 @default.
- W2024147785 cites W2124730089 @default.
- W2024147785 cites W2418531331 @default.
- W2024147785 doi "https://doi.org/10.1016/j.ics.2003.12.069" @default.
- W2024147785 hasPublicationYear "2004" @default.
- W2024147785 type Work @default.
- W2024147785 sameAs 2024147785 @default.
- W2024147785 citedByCount "0" @default.
- W2024147785 crossrefType "journal-article" @default.
- W2024147785 hasAuthorship W2024147785A5007883181 @default.
- W2024147785 hasAuthorship W2024147785A5020616386 @default.
- W2024147785 hasAuthorship W2024147785A5033938344 @default.
- W2024147785 hasAuthorship W2024147785A5088981771 @default.
- W2024147785 hasAuthorship W2024147785A5091529335 @default.
- W2024147785 hasConcept C104317684 @default.
- W2024147785 hasConcept C126322002 @default.
- W2024147785 hasConcept C134018914 @default.
- W2024147785 hasConcept C149011108 @default.
- W2024147785 hasConcept C176233148 @default.
- W2024147785 hasConcept C185592680 @default.
- W2024147785 hasConcept C2776439734 @default.
- W2024147785 hasConcept C2776779347 @default.
- W2024147785 hasConcept C2777374081 @default.
- W2024147785 hasConcept C2778514916 @default.
- W2024147785 hasConcept C2779280383 @default.
- W2024147785 hasConcept C513476851 @default.
- W2024147785 hasConcept C55493867 @default.
- W2024147785 hasConcept C555293320 @default.
- W2024147785 hasConcept C71924100 @default.
- W2024147785 hasConceptScore W2024147785C104317684 @default.
- W2024147785 hasConceptScore W2024147785C126322002 @default.
- W2024147785 hasConceptScore W2024147785C134018914 @default.
- W2024147785 hasConceptScore W2024147785C149011108 @default.
- W2024147785 hasConceptScore W2024147785C176233148 @default.
- W2024147785 hasConceptScore W2024147785C185592680 @default.
- W2024147785 hasConceptScore W2024147785C2776439734 @default.
- W2024147785 hasConceptScore W2024147785C2776779347 @default.
- W2024147785 hasConceptScore W2024147785C2777374081 @default.
- W2024147785 hasConceptScore W2024147785C2778514916 @default.
- W2024147785 hasConceptScore W2024147785C2779280383 @default.
- W2024147785 hasConceptScore W2024147785C513476851 @default.
- W2024147785 hasConceptScore W2024147785C55493867 @default.
- W2024147785 hasConceptScore W2024147785C555293320 @default.
- W2024147785 hasConceptScore W2024147785C71924100 @default.
- W2024147785 hasLocation W20241477851 @default.
- W2024147785 hasOpenAccess W2024147785 @default.
- W2024147785 hasPrimaryLocation W20241477851 @default.
- W2024147785 hasRelatedWork W1995853913 @default.
- W2024147785 hasRelatedWork W2003797084 @default.
- W2024147785 hasRelatedWork W2029739536 @default.
- W2024147785 hasRelatedWork W2084461439 @default.
- W2024147785 hasRelatedWork W2089926309 @default.
- W2024147785 hasRelatedWork W2093749606 @default.
- W2024147785 hasRelatedWork W2127396703 @default.
- W2024147785 hasRelatedWork W2324925659 @default.
- W2024147785 hasRelatedWork W2431483632 @default.
- W2024147785 hasRelatedWork W2887463556 @default.
- W2024147785 isParatext "false" @default.
- W2024147785 isRetracted "false" @default.
- W2024147785 magId "2024147785" @default.
- W2024147785 workType "article" @default.