FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024148299> ?p ?o ?g. }

• W2024148299 endingPage "64" @default.
• W2024148299 startingPage "55" @default.
• W2024148299 abstract "Peroxynitrite, the reaction product between superoxide (O(*2)) and nitric oxide (*NO), is a powerful oxidizing species that contributes to macrophage competence against pathogens. In this context, peroxynitrite appears to play an important role in controlling infection by Trypanosoma cruzi, the unicellular parasite responsible for Chagas disease. T. cruzi contains various enzyme systems for the decomposition of hydroperoxides, all of which involve the participation of the low-molecular-weight dithiol trypanothione (N(1),N(8)-bis(glutathionyl)spermidine) as a critical redox partner. A large fraction of the trypanothione-dependent antioxidant capacity of T. cruzi is linked to the tryparedoxin-tryparedoxin peroxidase system which has critical protein thiol groups. In this report we demonstrate that dihydrotrypanothione is readily consumed during peroxynitrite challenge to cells to yield the corresponding trypanothione disulfide. On the other hand, glutathione, which is present in T. cruzi at lower concentrations than trypanothione, is consumed to a much lesser extent and mainly evolves to glutathione-protein mixed disulfides. The inhibition of glutathione biosynthesis by buthionine sulfoximine, which decreases glutathione concentration to 10% of control after 20 h, neither affects the concentration of dihydrotrypanothione nor sensitizes T. cruzi to peroxynitrite-mediated cytotoxicity. On the other hand, pretreatment of T. cruzi with diamide, which leads to a significant depletion (>70%) of dihydrotrypanothione, largely increases the extent of cellular nitration and inhibition of cell growth caused by peroxynitrite. Altogether, our findings support a key protective role for dihydrotrypanothione and the trypanothione-dependent antioxidant system in T. cruzi against peroxynitrite, which may facilitate the survival of trypanosomes within the oxidative environment of activated macrophages." @default.
• W2024148299 created "2016-06-24" @default.
• W2024148299 creator A5038220750 @default.
• W2024148299 creator A5053069413 @default.
• W2024148299 creator A5073926538 @default.
• W2024148299 date "2003-04-01" @default.
• W2024148299 modified "2023-10-17" @default.
• W2024148299 title "The trypanothione–thiol system in Trypanosoma cruzi as a key antioxidant mechanism against peroxynitrite-mediated cytotoxicity" @default.
• W2024148299 cites W1489860413 @default.
• W2024148299 cites W1497458285 @default.
• W2024148299 cites W1498636565 @default.
• W2024148299 cites W1500094754 @default.
• W2024148299 cites W1506043065 @default.
• W2024148299 cites W1511153178 @default.
• W2024148299 cites W1563653502 @default.
• W2024148299 cites W1602425415 @default.
• W2024148299 cites W1604646983 @default.
• W2024148299 cites W1668019941 @default.
• W2024148299 cites W1709336739 @default.
• W2024148299 cites W1761291408 @default.
• W2024148299 cites W1821918060 @default.
• W2024148299 cites W1838953468 @default.
• W2024148299 cites W1940436875 @default.
• W2024148299 cites W1967388554 @default.
• W2024148299 cites W1970732978 @default.
• W2024148299 cites W1973258909 @default.
• W2024148299 cites W1974274242 @default.
• W2024148299 cites W1977849948 @default.
• W2024148299 cites W1979213367 @default.
• W2024148299 cites W1980119632 @default.
• W2024148299 cites W1984001765 @default.
• W2024148299 cites W1984677592 @default.
• W2024148299 cites W1987089638 @default.
• W2024148299 cites W1987787292 @default.
• W2024148299 cites W1992176634 @default.
• W2024148299 cites W1995457093 @default.
• W2024148299 cites W1996048275 @default.
• W2024148299 cites W2002604678 @default.
• W2024148299 cites W2002649836 @default.
• W2024148299 cites W2006370393 @default.
• W2024148299 cites W2008203769 @default.
• W2024148299 cites W2009279488 @default.
• W2024148299 cites W2010015373 @default.
• W2024148299 cites W2011344657 @default.
• W2024148299 cites W2011948827 @default.
• W2024148299 cites W2016066239 @default.
• W2024148299 cites W2018380711 @default.
• W2024148299 cites W2019859522 @default.
• W2024148299 cites W2020988577 @default.
• W2024148299 cites W2022377100 @default.
• W2024148299 cites W2034747589 @default.
• W2024148299 cites W2035718705 @default.
• W2024148299 cites W2039045136 @default.
• W2024148299 cites W2050757563 @default.
• W2024148299 cites W2052036604 @default.
• W2024148299 cites W2052075760 @default.
• W2024148299 cites W2053002124 @default.
• W2024148299 cites W2054930602 @default.
• W2024148299 cites W2057483650 @default.
• W2024148299 cites W2058456389 @default.
• W2024148299 cites W2063077244 @default.
• W2024148299 cites W2063463227 @default.
• W2024148299 cites W2065081966 @default.
• W2024148299 cites W2065796822 @default.
• W2024148299 cites W2067939107 @default.
• W2024148299 cites W2080206499 @default.
• W2024148299 cites W2085001449 @default.
• W2024148299 cites W2090316954 @default.
• W2024148299 cites W2091411145 @default.
• W2024148299 cites W2094019524 @default.
• W2024148299 cites W2094745968 @default.
• W2024148299 cites W2095214547 @default.
• W2024148299 cites W2095397074 @default.
• W2024148299 cites W2115659530 @default.
• W2024148299 cites W2142722961 @default.
• W2024148299 cites W2162084938 @default.
• W2024148299 cites W2166103882 @default.
• W2024148299 cites W2170051746 @default.
• W2024148299 cites W2321540468 @default.
• W2024148299 cites W2797857252 @default.
• W2024148299 cites W36185775 @default.
• W2024148299 cites W4245847222 @default.
• W2024148299 cites W4251130661 @default.
• W2024148299 cites W85036947 @default.
• W2024148299 cites W2117232507 @default.
• W2024148299 doi "https://doi.org/10.1016/s0003-9861(02)00745-2" @default.
• W2024148299 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12646268" @default.
• W2024148299 hasPublicationYear "2003" @default.
• W2024148299 type Work @default.
• W2024148299 sameAs 2024148299 @default.
• W2024148299 citedByCount "64" @default.
• W2024148299 countsByYear W20241482992012 @default.
• W2024148299 countsByYear W20241482992013 @default.
• W2024148299 countsByYear W20241482992014 @default.
• W2024148299 countsByYear W20241482992015 @default.
• W2024148299 countsByYear W20241482992017 @default.
• W2024148299 countsByYear W20241482992018 @default.
• W2024148299 countsByYear W20241482992019 @default.

• next