Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024149236> ?p ?o ?g. }
- W2024149236 endingPage "310" @default.
- W2024149236 startingPage "298" @default.
- W2024149236 abstract "Cancer stem cells (CSCs) are responsible for tumor initiation and progression. Toll-like receptors (TLRs) are highly expressed in cancer cells and associated with poor prognosis. However, a linkage between CSCs and TLRs is unclear, and potential intervention strategies to prevent TLR stimulation-induced CSC formation and underlying mechanisms are lacking. Here, we demonstrate that stimulation of toll-like receptor 3 (TLR3) promotes breast cancer cells toward a CSC phenotype in vitro and in vivo. Importantly, conventional NF-κB signaling pathway is not exclusively responsible for TLR3 activation-enriched CSCs. Intriguingly, simultaneous activation of both β-catenin and NF-κB signaling pathways, but neither alone, is required for the enhanced CSC phenotypes. We have further identified a small molecule cardamonin that can concurrently inhibit β-catenin and NF-κB signals. Cardamonin is capable of effectively abolishing TLR3 activation-enhanced CSC phenotypes in vitro and successfully controlling TLR3 stimulation-induced tumor growth in human breast cancer xenografts. These findings may provide a foundation for developing new strategies to prevent the induction of CSCs during cancer therapies." @default.
- W2024149236 created "2016-06-24" @default.
- W2024149236 creator A5009144350 @default.
- W2024149236 creator A5021063023 @default.
- W2024149236 creator A5033047541 @default.
- W2024149236 creator A5044395466 @default.
- W2024149236 creator A5047475750 @default.
- W2024149236 creator A5055220037 @default.
- W2024149236 creator A5065015809 @default.
- W2024149236 creator A5066082511 @default.
- W2024149236 creator A5079780359 @default.
- W2024149236 creator A5080996707 @default.
- W2024149236 date "2014-09-26" @default.
- W2024149236 modified "2023-10-18" @default.
- W2024149236 title "β-Catenin and NF-κB co-activation triggered by TLR3 stimulation facilitates stem cell-like phenotypes in breast cancer" @default.
- W2024149236 cites W1981876883 @default.
- W2024149236 cites W1984744520 @default.
- W2024149236 cites W2008797060 @default.
- W2024149236 cites W2009592273 @default.
- W2024149236 cites W2011366619 @default.
- W2024149236 cites W2014691022 @default.
- W2024149236 cites W2015649564 @default.
- W2024149236 cites W2021681810 @default.
- W2024149236 cites W2023427658 @default.
- W2024149236 cites W2023846533 @default.
- W2024149236 cites W2034450471 @default.
- W2024149236 cites W2039817035 @default.
- W2024149236 cites W2050300062 @default.
- W2024149236 cites W2053936287 @default.
- W2024149236 cites W2057646387 @default.
- W2024149236 cites W2062069198 @default.
- W2024149236 cites W2062530917 @default.
- W2024149236 cites W2067067950 @default.
- W2024149236 cites W2069264443 @default.
- W2024149236 cites W2076361525 @default.
- W2024149236 cites W2080457126 @default.
- W2024149236 cites W2083274861 @default.
- W2024149236 cites W2090163159 @default.
- W2024149236 cites W2090982381 @default.
- W2024149236 cites W2094704890 @default.
- W2024149236 cites W2095320189 @default.
- W2024149236 cites W2108674774 @default.
- W2024149236 cites W2109445380 @default.
- W2024149236 cites W2113334910 @default.
- W2024149236 cites W2119656037 @default.
- W2024149236 cites W2120656656 @default.
- W2024149236 cites W2123105952 @default.
- W2024149236 cites W2123509170 @default.
- W2024149236 cites W2134940821 @default.
- W2024149236 cites W2143841612 @default.
- W2024149236 cites W2155734873 @default.
- W2024149236 cites W2159640574 @default.
- W2024149236 cites W2161817637 @default.
- W2024149236 cites W2170185804 @default.
- W2024149236 cites W2170602872 @default.
- W2024149236 cites W4253186968 @default.
- W2024149236 doi "https://doi.org/10.1038/cdd.2014.145" @default.
- W2024149236 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4291491" @default.
- W2024149236 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25257174" @default.
- W2024149236 hasPublicationYear "2014" @default.
- W2024149236 type Work @default.
- W2024149236 sameAs 2024149236 @default.
- W2024149236 citedByCount "78" @default.
- W2024149236 countsByYear W20241492362015 @default.
- W2024149236 countsByYear W20241492362016 @default.
- W2024149236 countsByYear W20241492362017 @default.
- W2024149236 countsByYear W20241492362018 @default.
- W2024149236 countsByYear W20241492362019 @default.
- W2024149236 countsByYear W20241492362020 @default.
- W2024149236 countsByYear W20241492362021 @default.
- W2024149236 countsByYear W20241492362022 @default.
- W2024149236 countsByYear W20241492362023 @default.
- W2024149236 crossrefType "journal-article" @default.
- W2024149236 hasAuthorship W2024149236A5009144350 @default.
- W2024149236 hasAuthorship W2024149236A5021063023 @default.
- W2024149236 hasAuthorship W2024149236A5033047541 @default.
- W2024149236 hasAuthorship W2024149236A5044395466 @default.
- W2024149236 hasAuthorship W2024149236A5047475750 @default.
- W2024149236 hasAuthorship W2024149236A5055220037 @default.
- W2024149236 hasAuthorship W2024149236A5065015809 @default.
- W2024149236 hasAuthorship W2024149236A5066082511 @default.
- W2024149236 hasAuthorship W2024149236A5079780359 @default.
- W2024149236 hasAuthorship W2024149236A5080996707 @default.
- W2024149236 hasBestOaLocation W20241492361 @default.
- W2024149236 hasConcept C104317684 @default.
- W2024149236 hasConcept C121608353 @default.
- W2024149236 hasConcept C127716648 @default.
- W2024149236 hasConcept C136449434 @default.
- W2024149236 hasConcept C137620995 @default.
- W2024149236 hasConcept C203014093 @default.
- W2024149236 hasConcept C2776709828 @default.
- W2024149236 hasConcept C2778420691 @default.
- W2024149236 hasConcept C2779836521 @default.
- W2024149236 hasConcept C28328180 @default.
- W2024149236 hasConcept C502942594 @default.
- W2024149236 hasConcept C54355233 @default.
- W2024149236 hasConcept C55427017 @default.
- W2024149236 hasConcept C55493867 @default.