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- W2024150672 abstract "BACKGROUND Basal cell carcinoma (BCC) is the most common type of skin cancer treated by the dermatologic surgeon. The discovery that patients with the nevoid BCC syndrome had mutations in the human homologue of theDrosophilapatched gene led to a rapid increase in our understanding of the pathogenesis of BCC. It is theorized that altered regulation at multiple steps in the patched signal transduction pathway may contribute to the development of BCC. This pathway also plays an essential role in embryonic hair follicle development and during the hair cycle. Taken together, a considerable body of evidence suggests that at least some BCC may be derived from deregulated patched signaling in hair follicle stem cells. OBJECTIVE To review evidence of a follicular derivation of BCC and to highlight emerging therapeutic strategies to block deregulated patched signaling in BCC. CONCLUSION Deregulation of the patched signal transduction pathway is present in the vast majority of human BCCs. Pharmacologic inhibitors of this pathway may offer a therapeutic strategy to block tumor growth." @default.
- W2024150672 created "2016-06-24" @default.
- W2024150672 creator A5051153127 @default.
- W2024150672 date "2009-09-01" @default.
- W2024150672 modified "2023-09-27" @default.
- W2024150672 title "Review of the Hair Follicle Origin Hypothesis for Basal Cell Carcinoma" @default.
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- W2024150672 doi "https://doi.org/10.1111/j.1524-4725.2009.01236.x" @default.
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