FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024151787> ?p ?o ?g. }

• W2024151787 endingPage "329" @default.
• W2024151787 startingPage "320" @default.
• W2024151787 abstract "Deuterium isotope effects on the kinetic parameters for deamination and N-hydroxylation of cyclohexylamine (CHA) catalyzed by rabbit liver microsomes with NADPH are investigated. Both reactions are inhibited by carbon monoxide and have the characteristics of typical cytochrome P450-dependent monooxygenase reactions. A small and significant deuterium isotope effect operates in the oxidative deamination of CHA. The apparent isotope effects i.e., VHVD and (VK)H(VK ratios for deamination, are 1.75 and 1.8–2.3, respectively. On the basis of N-hydroxylation, the VHVD and VK ratios are 0.8–0.9. The N-hydroxylation rate of α-deuterated CHA (D-CHA) is somewhat higher than that of CHA. The increased increment of hydroxylamine formation seems to coincide with the decreased amount of deamination. Substitution of deuterium in the α-position of CHA results in metabolic switching of cytochrome P450 from deamination to N-hydroxylation with low deuterium isotope effects. The data are interpreted in terms of an initial one-electron abstraction from the nitrogen to form an aminium cation radical followed by recombination with iron-bound hydroxyl radical leading to N-hydroxylamine, or followed by α-carbon deprotonation to form a neutral carbon radical. The latter can lead to a carbinolamine intermediate for deamination by way of imine or recombination with nascent iron-bound hydroxyl radical. The relative rates of the reactions depend on the α-carbon deprotonation rates of amines." @default.
• W2024151787 created "2016-06-24" @default.
• W2024151787 creator A5025796554 @default.
• W2024151787 date "1989-04-01" @default.
• W2024151787 modified "2023-10-16" @default.
• W2024151787 title "Kinetic deuterium isotope effects on deamination and N-hydroxylation of cyclohexylamine by rabbit liver microsomes" @default.
• W2024151787 cites W1493176169 @default.
• W2024151787 cites W1575733808 @default.
• W2024151787 cites W1607549921 @default.
• W2024151787 cites W166229085 @default.
• W2024151787 cites W1676611497 @default.
• W2024151787 cites W1775749144 @default.
• W2024151787 cites W1964661815 @default.
• W2024151787 cites W1973976863 @default.
• W2024151787 cites W1975890176 @default.
• W2024151787 cites W1979855161 @default.
• W2024151787 cites W1980147496 @default.
• W2024151787 cites W1980759909 @default.
• W2024151787 cites W1982544104 @default.
• W2024151787 cites W1987229515 @default.
• W2024151787 cites W1994885527 @default.
• W2024151787 cites W2011349148 @default.
• W2024151787 cites W2012013416 @default.
• W2024151787 cites W2012456745 @default.
• W2024151787 cites W2026113844 @default.
• W2024151787 cites W2026902012 @default.
• W2024151787 cites W2036326073 @default.
• W2024151787 cites W2041513787 @default.
• W2024151787 cites W2050986823 @default.
• W2024151787 cites W2063249326 @default.
• W2024151787 cites W2064193868 @default.
• W2024151787 cites W2064690299 @default.
• W2024151787 cites W2065506376 @default.
• W2024151787 cites W2070156597 @default.
• W2024151787 cites W2080232910 @default.
• W2024151787 cites W2082905972 @default.
• W2024151787 cites W2090988649 @default.
• W2024151787 cites W2091222455 @default.
• W2024151787 cites W2095285273 @default.
• W2024151787 cites W2095441596 @default.
• W2024151787 cites W2130327573 @default.
• W2024151787 cites W2155745521 @default.
• W2024151787 cites W2169838870 @default.
• W2024151787 cites W2281564613 @default.
• W2024151787 cites W2321409224 @default.
• W2024151787 cites W2326680499 @default.
• W2024151787 cites W2330302743 @default.
• W2024151787 cites W2330563951 @default.
• W2024151787 cites W2949245371 @default.
• W2024151787 cites W300228291 @default.
• W2024151787 cites W69165361 @default.
• W2024151787 doi "https://doi.org/10.1016/0003-9861(89)90034-9" @default.
• W2024151787 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2930194" @default.
• W2024151787 hasPublicationYear "1989" @default.
• W2024151787 type Work @default.
• W2024151787 sameAs 2024151787 @default.
• W2024151787 citedByCount "10" @default.
• W2024151787 crossrefType "journal-article" @default.
• W2024151787 hasAuthorship W2024151787A5025796554 @default.
• W2024151787 hasConcept C118629725 @default.
• W2024151787 hasConcept C121332964 @default.
• W2024151787 hasConcept C145148216 @default.
• W2024151787 hasConcept C145782189 @default.
• W2024151787 hasConcept C155647269 @default.
• W2024151787 hasConcept C161790260 @default.
• W2024151787 hasConcept C178790620 @default.
• W2024151787 hasConcept C181199279 @default.
• W2024151787 hasConcept C185592680 @default.
• W2024151787 hasConcept C197974221 @default.
• W2024151787 hasConcept C2775999725 @default.
• W2024151787 hasConcept C2777346864 @default.
• W2024151787 hasConcept C2780595602 @default.
• W2024151787 hasConcept C2781109383 @default.
• W2024151787 hasConcept C58364064 @default.
• W2024151787 hasConcept C62520636 @default.
• W2024151787 hasConcept C69928629 @default.
• W2024151787 hasConcept C75473681 @default.
• W2024151787 hasConceptScore W2024151787C118629725 @default.
• W2024151787 hasConceptScore W2024151787C121332964 @default.
• W2024151787 hasConceptScore W2024151787C145148216 @default.
• W2024151787 hasConceptScore W2024151787C145782189 @default.
• W2024151787 hasConceptScore W2024151787C155647269 @default.
• W2024151787 hasConceptScore W2024151787C161790260 @default.
• W2024151787 hasConceptScore W2024151787C178790620 @default.
• W2024151787 hasConceptScore W2024151787C181199279 @default.
• W2024151787 hasConceptScore W2024151787C185592680 @default.
• W2024151787 hasConceptScore W2024151787C197974221 @default.
• W2024151787 hasConceptScore W2024151787C2775999725 @default.
• W2024151787 hasConceptScore W2024151787C2777346864 @default.
• W2024151787 hasConceptScore W2024151787C2780595602 @default.
• W2024151787 hasConceptScore W2024151787C2781109383 @default.
• W2024151787 hasConceptScore W2024151787C58364064 @default.
• W2024151787 hasConceptScore W2024151787C62520636 @default.
• W2024151787 hasConceptScore W2024151787C69928629 @default.
• W2024151787 hasConceptScore W2024151787C75473681 @default.
• W2024151787 hasIssue "1" @default.
• W2024151787 hasLocation W20241517871 @default.
• W2024151787 hasLocation W20241517872 @default.

• next