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• W2024155189 abstract "A novel isochroman carboxylic acid CJ-12, 373 was isolated from Penicillium sp. CL22557. CJ-12, 373 inhibits both DNA gyrase-mediated supercoiling and relaxation without the formation of a cleavage intermediate, suggesting that CJ-12, 373 inhibits DNA gyrase at a stage distinct from the religation step. CJ-12, 373 is not selective for procaryotic DNA gyrase as it also inhibits relaxation mediated by eukaryotic topoisomerase II. The antimicrobial potency of CJ-12, 373, however, is largely attributed to its inhibition of DNA gyrase." @default.
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• W2024155189 date "1998-01-01" @default.
• W2024155189 modified "2023-10-16" @default.
• W2024155189 title "CJ-12,373, a Novel Topoisomerase II Inhibitor: Fermentation, Isolation, Structure Elucidation and Biological Activities." @default.
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• W2024155189 doi "https://doi.org/10.7164/antibiotics.51.112" @default.
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