FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024157575> ?p ?o ?g. }

• W2024157575 endingPage "E1334" @default.
• W2024157575 startingPage "E1334" @default.
• W2024157575 abstract "OBJECTIVE Melanotic schwannoma is a rare neoplasm, classifiable as a peripheral nerve sheath tumor, and differentiated from a typical schwannoma by heavy pigmentation. Psammoma bodies can be visualized in more than 50% of melanotic schwannomas. Half of patients with such “psammomatous melanotic schwannomas” have Carney complex, a dominantly transmitted autosomal disorder. Most recently, the tumor suppressor gene, PRKAR1A, coding for the Type 1α regulatory subunit of protein kinase A was found to be mutated in approximately half of the known Carney complex families. Although cranial schwannomas have been described in patients with Carney complex, their numbers are too small to be considered a definite part of the syndrome. Furthermore, only melanotic schwannomas with psammoma bodies are included as diagnostic criteria for Carney complex. The objective of this report is to communicate a case of trigeminal nonpsammomatous melanotic schwannoma as the first manifestation of Carney complex. CLINICAL PRESENTATION A 34-year-old woman presented with odontalgia, right V3 hypoesthesia, V2 paresthesia, and diplopia. Magnetic resonance imaging scans of the brain revealed a small tumor with homogenous contrast in the right trigeminal pathway. INTERVENTION We performed an extradural approach to the right cavernous sinus by a middle fossa approach. The lateral wall was opened between the cranial nerves, and a soft and black tumor was resected in a piecemeal fashion. Histology and immunohistochemical analysis of the tumor were compatible with melanotic schwannoma, but no psammomatous bodies were identified. Endocrine evaluation showed that this patient's symptoms fulfilled the diagnostic criteria of Carney complex, with lentiginosis, multiple breast ductal adenomas, multiple hypoechoic nodules on thyroid ultrasonography, and a 4 × 5-cm asymptomatic atrial cardiac myxoma, which was removed 15 days after the neurosurgery. Three months later, a recurrence of melanotic schwannoma was identified. Molecular analyses of genomic and somatic deoxyribonucleic acid from the patient found a 578 to 579delTG mutation of PRKAR1A. CONCLUSION We present the unusual case of a nonpsammomatous trigeminal melanotic schwannoma associated with Carney complex, with confirmed PRKAR1A gene mutation. Our case highlights that neurosurgeons, in the presence of a melanotic schwannoma, should be aware of the features of the Carney complex because, in such cases, pre- and postoperative management is significantly affected. We also postulate that the absence of psammoma bodies or cranial localization do not exclude this diagnosis." @default.
• W2024157575 created "2016-06-24" @default.
• W2024157575 creator A5025033427 @default.
• W2024157575 creator A5047689220 @default.
• W2024157575 creator A5060104219 @default.
• W2024157575 creator A5076821793 @default.
• W2024157575 creator A5079769815 @default.
• W2024157575 date "2006-12-01" @default.
• W2024157575 modified "2023-10-17" @default.
• W2024157575 title "MELANOTIC NONPSAMMOMATOUS TRIGEMINAL SCHWANNOMA AS THE FIRST MANIFESTATION OF CARNEY COMPLEX" @default.
• W2024157575 cites W2003031877 @default.
• W2024157575 cites W2008227227 @default.
• W2024157575 cites W2047597784 @default.
• W2024157575 cites W2059936847 @default.
• W2024157575 cites W2070835256 @default.
• W2024157575 cites W2090290392 @default.
• W2024157575 cites W2117535295 @default.
• W2024157575 cites W2124127909 @default.
• W2024157575 cites W2125954501 @default.
• W2024157575 cites W3193127251 @default.
• W2024157575 cites W4252883187 @default.
• W2024157575 cites W4293043787 @default.
• W2024157575 cites W4297923706 @default.
• W2024157575 doi "https://doi.org/10.1227/01.neu.0000245608.07570.d2" @default.
• W2024157575 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17277668" @default.
• W2024157575 hasPublicationYear "2006" @default.
• W2024157575 type Work @default.
• W2024157575 sameAs 2024157575 @default.
• W2024157575 citedByCount "22" @default.
• W2024157575 countsByYear W20241575752012 @default.
• W2024157575 countsByYear W20241575752013 @default.
• W2024157575 countsByYear W20241575752016 @default.
• W2024157575 countsByYear W20241575752017 @default.
• W2024157575 countsByYear W20241575752018 @default.
• W2024157575 countsByYear W20241575752019 @default.
• W2024157575 countsByYear W20241575752022 @default.
• W2024157575 countsByYear W20241575752023 @default.
• W2024157575 crossrefType "journal-article" @default.
• W2024157575 hasAuthorship W2024157575A5025033427 @default.
• W2024157575 hasAuthorship W2024157575A5047689220 @default.
• W2024157575 hasAuthorship W2024157575A5060104219 @default.
• W2024157575 hasAuthorship W2024157575A5076821793 @default.
• W2024157575 hasAuthorship W2024157575A5079769815 @default.
• W2024157575 hasBestOaLocation W20241575751 @default.
• W2024157575 hasConcept C104317684 @default.
• W2024157575 hasConcept C105702510 @default.
• W2024157575 hasConcept C142724271 @default.
• W2024157575 hasConcept C174865614 @default.
• W2024157575 hasConcept C185592680 @default.
• W2024157575 hasConcept C204232928 @default.
• W2024157575 hasConcept C2776734335 @default.
• W2024157575 hasConcept C2777108446 @default.
• W2024157575 hasConcept C2777397368 @default.
• W2024157575 hasConcept C2781447767 @default.
• W2024157575 hasConcept C55493867 @default.
• W2024157575 hasConcept C71924100 @default.
• W2024157575 hasConceptScore W2024157575C104317684 @default.
• W2024157575 hasConceptScore W2024157575C105702510 @default.
• W2024157575 hasConceptScore W2024157575C142724271 @default.
• W2024157575 hasConceptScore W2024157575C174865614 @default.
• W2024157575 hasConceptScore W2024157575C185592680 @default.
• W2024157575 hasConceptScore W2024157575C204232928 @default.
• W2024157575 hasConceptScore W2024157575C2776734335 @default.
• W2024157575 hasConceptScore W2024157575C2777108446 @default.
• W2024157575 hasConceptScore W2024157575C2777397368 @default.
• W2024157575 hasConceptScore W2024157575C2781447767 @default.
• W2024157575 hasConceptScore W2024157575C55493867 @default.
• W2024157575 hasConceptScore W2024157575C71924100 @default.
• W2024157575 hasIssue "6" @default.
• W2024157575 hasLocation W20241575751 @default.
• W2024157575 hasLocation W20241575752 @default.
• W2024157575 hasOpenAccess W2024157575 @default.
• W2024157575 hasPrimaryLocation W20241575751 @default.
• W2024157575 hasRelatedWork W191005484 @default.
• W2024157575 hasRelatedWork W2013318299 @default.
• W2024157575 hasRelatedWork W2020969308 @default.
• W2024157575 hasRelatedWork W2024157575 @default.
• W2024157575 hasRelatedWork W2083161229 @default.
• W2024157575 hasRelatedWork W2141227190 @default.
• W2024157575 hasRelatedWork W2316147236 @default.
• W2024157575 hasRelatedWork W2411560988 @default.
• W2024157575 hasRelatedWork W2784502327 @default.
• W2024157575 hasRelatedWork W4289132439 @default.
• W2024157575 hasVolume "59" @default.
• W2024157575 isParatext "false" @default.
• W2024157575 isRetracted "false" @default.
• W2024157575 magId "2024157575" @default.
• W2024157575 workType "article" @default.