Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024157577> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W2024157577 endingPage "1639" @default.
- W2024157577 startingPage "1633" @default.
- W2024157577 abstract "The purpose of this study was to assess pituitary gonadotropins and free testosterone levels in a larger cohort of men with Alzheimer's disease (AD, n=112) and age-matched controls (n=98) from the Oxford Project to Investigate Memory and Ageing (OPTIMA). We measured gonadotropins (follicle stimulating hormone, FSH, and luteinizing hormone, LH), sex hormone binding globulin (SHBG, which determines the amount of free testosterone) and total testosterone (TT) using enzyme immunoassays. AD cases had significantly higher LH and FSH and lower free testosterone levels. LH, FSH and SHBG all increased with age, while free testosterone decreased. Low free testosterone was an independent predictor for AD. Its variance was overall explained by high SHBG, low TT, high LH, an older age and low body mass index (BMI). In controls, low thyroid stimulating hormone levels were also associated with low free testosterone. Elderly AD cases had raised levels of gonadotropins. This response may be an attempt to normalize low free testosterone levels. In non-demented participants, subclinical hyperthyroid disease (a risk factor for AD) which can result in higher SHBG levels, was associated with low free testosterone. Lowering SHBG and/or screening for subclinical thyroid disease may prevent cognitive decline and/or wasting in men at risk for AD." @default.
- W2024157577 created "2016-06-24" @default.
- W2024157577 creator A5014406538 @default.
- W2024157577 creator A5030330229 @default.
- W2024157577 creator A5053039076 @default.
- W2024157577 creator A5082404726 @default.
- W2024157577 date "2004-11-01" @default.
- W2024157577 modified "2023-10-18" @default.
- W2024157577 title "Low free testosterone is an independent risk factor for Alzheimer's disease" @default.
- W2024157577 cites W1503655230 @default.
- W2024157577 cites W1948684271 @default.
- W2024157577 cites W1981129287 @default.
- W2024157577 cites W1988940818 @default.
- W2024157577 cites W1991219488 @default.
- W2024157577 cites W1992951943 @default.
- W2024157577 cites W2001676697 @default.
- W2024157577 cites W2019247935 @default.
- W2024157577 cites W2020111990 @default.
- W2024157577 cites W2035997119 @default.
- W2024157577 cites W2037301299 @default.
- W2024157577 cites W2052986007 @default.
- W2024157577 cites W2058492963 @default.
- W2024157577 cites W2060803759 @default.
- W2024157577 cites W2060941195 @default.
- W2024157577 cites W2099614709 @default.
- W2024157577 cites W2102240367 @default.
- W2024157577 cites W2133910658 @default.
- W2024157577 cites W2146729934 @default.
- W2024157577 cites W2156220037 @default.
- W2024157577 doi "https://doi.org/10.1016/j.exger.2004.06.019" @default.
- W2024157577 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15582279" @default.
- W2024157577 hasPublicationYear "2004" @default.
- W2024157577 type Work @default.
- W2024157577 sameAs 2024157577 @default.
- W2024157577 citedByCount "165" @default.
- W2024157577 countsByYear W20241575772012 @default.
- W2024157577 countsByYear W20241575772013 @default.
- W2024157577 countsByYear W20241575772014 @default.
- W2024157577 countsByYear W20241575772015 @default.
- W2024157577 countsByYear W20241575772016 @default.
- W2024157577 countsByYear W20241575772017 @default.
- W2024157577 countsByYear W20241575772018 @default.
- W2024157577 countsByYear W20241575772019 @default.
- W2024157577 countsByYear W20241575772020 @default.
- W2024157577 countsByYear W20241575772021 @default.
- W2024157577 countsByYear W20241575772022 @default.
- W2024157577 countsByYear W20241575772023 @default.
- W2024157577 crossrefType "journal-article" @default.
- W2024157577 hasAuthorship W2024157577A5014406538 @default.
- W2024157577 hasAuthorship W2024157577A5030330229 @default.
- W2024157577 hasAuthorship W2024157577A5053039076 @default.
- W2024157577 hasAuthorship W2024157577A5082404726 @default.
- W2024157577 hasConcept C113280763 @default.
- W2024157577 hasConcept C126322002 @default.
- W2024157577 hasConcept C134018914 @default.
- W2024157577 hasConcept C2777911890 @default.
- W2024157577 hasConcept C2778575703 @default.
- W2024157577 hasConcept C2779279165 @default.
- W2024157577 hasConcept C2779279991 @default.
- W2024157577 hasConcept C2910497653 @default.
- W2024157577 hasConcept C30092816 @default.
- W2024157577 hasConcept C71315377 @default.
- W2024157577 hasConcept C71924100 @default.
- W2024157577 hasConceptScore W2024157577C113280763 @default.
- W2024157577 hasConceptScore W2024157577C126322002 @default.
- W2024157577 hasConceptScore W2024157577C134018914 @default.
- W2024157577 hasConceptScore W2024157577C2777911890 @default.
- W2024157577 hasConceptScore W2024157577C2778575703 @default.
- W2024157577 hasConceptScore W2024157577C2779279165 @default.
- W2024157577 hasConceptScore W2024157577C2779279991 @default.
- W2024157577 hasConceptScore W2024157577C2910497653 @default.
- W2024157577 hasConceptScore W2024157577C30092816 @default.
- W2024157577 hasConceptScore W2024157577C71315377 @default.
- W2024157577 hasConceptScore W2024157577C71924100 @default.
- W2024157577 hasIssue "11-12" @default.
- W2024157577 hasLocation W20241575771 @default.
- W2024157577 hasLocation W20241575772 @default.
- W2024157577 hasOpenAccess W2024157577 @default.
- W2024157577 hasPrimaryLocation W20241575771 @default.
- W2024157577 hasRelatedWork W1991634850 @default.
- W2024157577 hasRelatedWork W1992141591 @default.
- W2024157577 hasRelatedWork W2006690885 @default.
- W2024157577 hasRelatedWork W2026882188 @default.
- W2024157577 hasRelatedWork W2064034534 @default.
- W2024157577 hasRelatedWork W2067256679 @default.
- W2024157577 hasRelatedWork W2110179146 @default.
- W2024157577 hasRelatedWork W2118471439 @default.
- W2024157577 hasRelatedWork W2367428026 @default.
- W2024157577 hasRelatedWork W2411910748 @default.
- W2024157577 hasVolume "39" @default.
- W2024157577 isParatext "false" @default.
- W2024157577 isRetracted "false" @default.
- W2024157577 magId "2024157577" @default.
- W2024157577 workType "article" @default.