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• W2024157622 startingPage "361" @default.
• W2024157622 abstract "Current treatment approaches to the problem of obstructive sleep apnoea (OSA) have limitations. Specifically, invasive anatomical-based surgery and dental appliances typically do not alleviate obstruction at an acceptable rate, and compliance to continuous positive airway pressure (CPAP) devices is frequently suboptimal. Neurotoxinological treatment approaches are widespread in the field of medicine, but as yet have not been evaluated as a treatment for sleep-disordered breathing. In this review, it is argued that despite widespread recognition of the loss of upper airway (UA) muscular tone and/or reflexes in the expression of OSA, most treatment interventions to date have focused on anatomical principles alone. Several hypothesised neurotoxinological interventions aimed at either enhancing UA neuromuscular tone and/or reflexes are proposed, and some preliminary data is presented. Although in its early infancy, with considerable toxicity studies in animals yet to be done, a neurotoxinological approach to the problem of OSA holds promise as a future treatment, with the potential for both high effectiveness and patient compliance." @default.
• W2024157622 created "2016-06-24" @default.
• W2024157622 creator A5022164053 @default.
• W2024157622 creator A5038901302 @default.
• W2024157622 creator A5040849398 @default.
• W2024157622 creator A5064200556 @default.
• W2024157622 creator A5068823277 @default.
• W2024157622 creator A5088278023 @default.
• W2024157622 date "2007-10-01" @default.
• W2024157622 modified "2023-09-23" @default.
• W2024157622 title "A neurotoxinological approach to the treatment of obstructive sleep apnoea" @default.
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