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• W2024162554 endingPage "2619" @default.
• W2024162554 startingPage "2611" @default.
• W2024162554 abstract "BST-2/CD317/tetherin is a host factor that inhibits the release of HIV-1 and other unrelated viruses. A current model proposes that BST-2 physically tethers virions to the surface of virus-producing cells. The HIV-1-encoded Vpu protein effectively antagonizes the activity of BST-2. How Vpu accomplishes this task remains unclear; however, it is known that Vpu has the ability to down-modulate BST-2 from the cell surface. Here we analyzed the effects of Vpu on BST-2 by performing a series of kinetic studies with HeLa, 293T, and CEMx174 cells. Our results indicate that the surface downregulation of BST-2 is not due to an accelerated internalization or reduced recycling of internalized BST-2 but instead is caused by interference with the resupply of newly synthesized BST-2 from within the cell. While our data confirm previous reports that the high-level expression of Vpu can cause the endoplasmic reticulum (ER)-associated degradation of BST-2, we found no evidence that Vpu targets endogenous BST-2 in the ER in the course of a viral infection. Instead, we found that Vpu acts in a post-ER compartment and increases the turnover of newly synthesized mature BST-2. Our observation that Vpu does not affect the recycling of BST-2 suggests that Vpu does not act directly at the cell surface but may interfere with the trafficking of newly synthesized BST-2 to the cell surface, resulting in the accelerated targeting of BST-2 to the lysosomal compartment for degradation." @default.
• W2024162554 created "2016-06-24" @default.
• W2024162554 creator A5006448706 @default.
• W2024162554 creator A5029942701 @default.
• W2024162554 creator A5038390972 @default.
• W2024162554 date "2011-03-15" @default.
• W2024162554 modified "2023-10-16" @default.
• W2024162554 title "Differential Effects of Human Immunodeficiency Virus Type 1 Vpu on the Stability of BST-2/Tetherin" @default.
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• W2024162554 doi "https://doi.org/10.1128/jvi.02080-10" @default.
• W2024162554 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3067951" @default.
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• W2024162554 hasPublicationYear "2011" @default.
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