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• W2024162590 abstract "We have studied the interaction of CnErg1, a member of the γ-KTX subfamily of scorpion toxins with the inactivation-deficient S631A hERG channel. In the background of this mutation, we observed a mechanistic switch from turret block, characteristic of the action of γ-KTXs on Kv11-type channels, to pore plugging, characteristic of α-KTX block of Kv1-type channels. We suggest this reflects destabilization of the outer pore (turret region) of hERG allowing access of the toxin molecule to directly plug the conduction pathway." @default.
• W2024162590 created "2016-06-24" @default.
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• W2024162590 date "2007-09-01" @default.
• W2024162590 modified "2023-09-28" @default.
• W2024162590 title "The S631A Mutation Causes a Mechanistic Switch in the Block of hERG Channels by CnErg1" @default.
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• W2024162590 doi "https://doi.org/10.1529/biophysj.107.114561" @default.
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