FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024162852> ?p ?o ?g. }

• W2024162852 endingPage "736" @default.
• W2024162852 startingPage "728" @default.
• W2024162852 abstract "Physiologic concentrations of urate in solution had a clear and dosage-dependent suppressive effect on the concomitant uptake of radioiodinated human serum albumin (131I-HSA) during the ingestion of particles (bacteria) by human polymorphonuclear leukocytes (PMN). The effect was rapid, reversible on washing the cells, and demonstrable over a wide range of incubation times and ratios of particles to PMN. In this method, the incubated cells are washed, and most surface radio-activity is thereby removed; the amount of label trapped during particle ingestion then usually provides a sensitive measure of phagocytosis. However, no evidence for an effect of urate on phagocytosis was found by use of several other methods for the assessment of particle uptake, including 1) direct microscopic counts of cell-associated bacteria, 2) studies in which the bacteria were radiolabeled (instead of the media), and 3) the quantitative recovery of surviving bacteria from the media and from disrupted cells. An alternative explanation for the results with 131I-HSA is that urate interferes reversibly with the binding of albumin to the cell membrane, including those portions that become internalized during phagocytosis, thereby creating the false impression of less phagocytosis, when there is really only less trapped label (i.e., albumin). In fact, non-phagocytizing leukocytes—which do not transport albumin across the cell membrane—incubated in serum-buffer with added urate and with 131I-HSA and then drained (not washed) had much less cell-associated radioactivity than controls without added urate. Washing removed the difference (and most of the label from both groups). Crystals of urate and of silica are known to kill the cells that ingest them by disrupting the membranes of phagolysosomes, but only after protective protein has been digested. In the presence of dissolved urate, this inflammatory mechanism might be augmented by the relative lack of protective, membrane-associated protein. Indeed, as measured by the release of lactic dehydrogenase, injury to cells given silica crystals was augmented considerably in the presence of dissolved urate." @default.
• W2024162852 created "2016-06-24" @default.
• W2024162852 creator A5020549745 @default.
• W2024162852 creator A5021818271 @default.
• W2024162852 creator A5056736766 @default.
• W2024162852 creator A5090072507 @default.
• W2024162852 date "1979-07-01" @default.
• W2024162852 modified "2023-09-24" @default.
• W2024162852 title "The phlogistic potential of urate in solution" @default.
• W2024162852 cites W1489309412 @default.
• W2024162852 cites W182504489 @default.
• W2024162852 cites W1952575201 @default.
• W2024162852 cites W1957020011 @default.
• W2024162852 cites W1970457792 @default.
• W2024162852 cites W1991918785 @default.
• W2024162852 cites W1992405112 @default.
• W2024162852 cites W1996628507 @default.
• W2024162852 cites W2004779104 @default.
• W2024162852 cites W2039654337 @default.
• W2024162852 cites W2040609521 @default.
• W2024162852 cites W2095996385 @default.
• W2024162852 cites W2099100804 @default.
• W2024162852 cites W2111031157 @default.
• W2024162852 cites W2124023389 @default.
• W2024162852 cites W2129441674 @default.
• W2024162852 cites W2148499331 @default.
• W2024162852 cites W2603461932 @default.
• W2024162852 cites W4242811040 @default.
• W2024162852 cites W4300060781 @default.
• W2024162852 doi "https://doi.org/10.1002/art.1780220706" @default.
• W2024162852 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/222299" @default.
• W2024162852 hasPublicationYear "1979" @default.
• W2024162852 type Work @default.
• W2024162852 sameAs 2024162852 @default.
• W2024162852 citedByCount "12" @default.
• W2024162852 crossrefType "journal-article" @default.
• W2024162852 hasAuthorship W2024162852A5020549745 @default.
• W2024162852 hasAuthorship W2024162852A5021818271 @default.
• W2024162852 hasAuthorship W2024162852A5056736766 @default.
• W2024162852 hasAuthorship W2024162852A5090072507 @default.
• W2024162852 hasConcept C12554922 @default.
• W2024162852 hasConcept C1491633281 @default.
• W2024162852 hasConcept C160448771 @default.
• W2024162852 hasConcept C165616093 @default.
• W2024162852 hasConcept C185592680 @default.
• W2024162852 hasConcept C193230392 @default.
• W2024162852 hasConcept C25642318 @default.
• W2024162852 hasConcept C2776125364 @default.
• W2024162852 hasConcept C2778106830 @default.
• W2024162852 hasConcept C2778597219 @default.
• W2024162852 hasConcept C2910172971 @default.
• W2024162852 hasConcept C523546767 @default.
• W2024162852 hasConcept C54355233 @default.
• W2024162852 hasConcept C55493867 @default.
• W2024162852 hasConcept C86803240 @default.
• W2024162852 hasConcept C86807702 @default.
• W2024162852 hasConcept C89423630 @default.
• W2024162852 hasConceptScore W2024162852C12554922 @default.
• W2024162852 hasConceptScore W2024162852C1491633281 @default.
• W2024162852 hasConceptScore W2024162852C160448771 @default.
• W2024162852 hasConceptScore W2024162852C165616093 @default.
• W2024162852 hasConceptScore W2024162852C185592680 @default.
• W2024162852 hasConceptScore W2024162852C193230392 @default.
• W2024162852 hasConceptScore W2024162852C25642318 @default.
• W2024162852 hasConceptScore W2024162852C2776125364 @default.
• W2024162852 hasConceptScore W2024162852C2778106830 @default.
• W2024162852 hasConceptScore W2024162852C2778597219 @default.
• W2024162852 hasConceptScore W2024162852C2910172971 @default.
• W2024162852 hasConceptScore W2024162852C523546767 @default.
• W2024162852 hasConceptScore W2024162852C54355233 @default.
• W2024162852 hasConceptScore W2024162852C55493867 @default.
• W2024162852 hasConceptScore W2024162852C86803240 @default.
• W2024162852 hasConceptScore W2024162852C86807702 @default.
• W2024162852 hasConceptScore W2024162852C89423630 @default.
• W2024162852 hasIssue "7" @default.
• W2024162852 hasLocation W20241628521 @default.
• W2024162852 hasLocation W20241628522 @default.
• W2024162852 hasOpenAccess W2024162852 @default.
• W2024162852 hasPrimaryLocation W20241628521 @default.
• W2024162852 hasRelatedWork W1554355790 @default.
• W2024162852 hasRelatedWork W1574592059 @default.
• W2024162852 hasRelatedWork W1992957793 @default.
• W2024162852 hasRelatedWork W2006224427 @default.
• W2024162852 hasRelatedWork W2024162852 @default.
• W2024162852 hasRelatedWork W2077362383 @default.
• W2024162852 hasRelatedWork W2094603426 @default.
• W2024162852 hasRelatedWork W2131485520 @default.
• W2024162852 hasRelatedWork W2421639383 @default.
• W2024162852 hasRelatedWork W2435828662 @default.
• W2024162852 hasVolume "22" @default.
• W2024162852 isParatext "false" @default.
• W2024162852 isRetracted "false" @default.
• W2024162852 magId "2024162852" @default.
• W2024162852 workType "article" @default.