Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024165310> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2024165310 endingPage "505" @default.
- W2024165310 startingPage "497" @default.
- W2024165310 abstract "Our aim is to investigate whether peroxisome proliferator‐activator receptor‐γ (PPARγ) expression was altered in human mesangial cells under inflammatory stress and whether PPARγ could retard the inflammatory responses. Based on cultured human mesangial cell lines (HMCLs), PPARγ expressions at protein and mRNA levels were observed by Western blot analysis and reverse transcriptase polymerase chain reaction. Informatory cytokines such as tumor necrosis factor‐α (TNF‐α) and interleukin‐6 (IL‐6) were measured by enzyme‐linked immunosorbent assay. Our results demonstrated that PPARγ protein expression was dramatically increased in HMCLs stimulated by IL‐1β (10 ng/mL). The levels of IL‐6 and TNF‐α in HMCL supernatants, protein, and mRNA expressions of PPARγ in IL‐1β challenge cells were significantly increased more than those in untreated cells. Importantly, PPARγ agonists troglitazone, rosiglitazone, and 15‐deoxy‐Δ12,14‐prosglandin J2 significantly decreased the up expression of TNF‐α and IL‐6 in HMCL supernatants stimulated by IL‐1β. Furthermore, troglitazone downregulated TNF‐α and IL‐6 mRNA expression from IL‐1β challenge HMCLs. Our data suggest that PPARγ plays an important role in mesangial cells responding to inflammatory stress. PPARγ may prove to be a pharmacological target in glomerulonephritis." @default.
- W2024165310 created "2016-06-24" @default.
- W2024165310 creator A5010558103 @default.
- W2024165310 creator A5015104749 @default.
- W2024165310 creator A5022728200 @default.
- W2024165310 creator A5044980184 @default.
- W2024165310 creator A5080701348 @default.
- W2024165310 date "2004-01-01" @default.
- W2024165310 modified "2023-10-18" @default.
- W2024165310 title "Anti‐inflammatory Effect of PPARγ in Cultured Human Mesangial Cells" @default.
- W2024165310 cites W1505047300 @default.
- W2024165310 cites W1633340712 @default.
- W2024165310 cites W1639924204 @default.
- W2024165310 cites W1671834350 @default.
- W2024165310 cites W1963713924 @default.
- W2024165310 cites W1973012603 @default.
- W2024165310 cites W1976621212 @default.
- W2024165310 cites W1979761686 @default.
- W2024165310 cites W1990641914 @default.
- W2024165310 cites W1997892364 @default.
- W2024165310 cites W2003115027 @default.
- W2024165310 cites W2025456794 @default.
- W2024165310 cites W2032150705 @default.
- W2024165310 cites W2035838779 @default.
- W2024165310 cites W2051159435 @default.
- W2024165310 cites W2077000982 @default.
- W2024165310 cites W2116329239 @default.
- W2024165310 cites W2126801791 @default.
- W2024165310 doi "https://doi.org/10.1081/jdi-200031747" @default.
- W2024165310 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15526907" @default.
- W2024165310 hasPublicationYear "2004" @default.
- W2024165310 type Work @default.
- W2024165310 sameAs 2024165310 @default.
- W2024165310 citedByCount "18" @default.
- W2024165310 countsByYear W20241653102014 @default.
- W2024165310 countsByYear W20241653102016 @default.
- W2024165310 countsByYear W20241653102018 @default.
- W2024165310 countsByYear W20241653102021 @default.
- W2024165310 crossrefType "journal-article" @default.
- W2024165310 hasAuthorship W2024165310A5010558103 @default.
- W2024165310 hasAuthorship W2024165310A5015104749 @default.
- W2024165310 hasAuthorship W2024165310A5022728200 @default.
- W2024165310 hasAuthorship W2024165310A5044980184 @default.
- W2024165310 hasAuthorship W2024165310A5080701348 @default.
- W2024165310 hasConcept C104317684 @default.
- W2024165310 hasConcept C126322002 @default.
- W2024165310 hasConcept C134018914 @default.
- W2024165310 hasConcept C153911025 @default.
- W2024165310 hasConcept C170493617 @default.
- W2024165310 hasConcept C17991360 @default.
- W2024165310 hasConcept C187345961 @default.
- W2024165310 hasConcept C2776415932 @default.
- W2024165310 hasConcept C2778150266 @default.
- W2024165310 hasConcept C2779131090 @default.
- W2024165310 hasConcept C2780091579 @default.
- W2024165310 hasConcept C2780152017 @default.
- W2024165310 hasConcept C55493867 @default.
- W2024165310 hasConcept C71924100 @default.
- W2024165310 hasConcept C85265743 @default.
- W2024165310 hasConcept C86803240 @default.
- W2024165310 hasConceptScore W2024165310C104317684 @default.
- W2024165310 hasConceptScore W2024165310C126322002 @default.
- W2024165310 hasConceptScore W2024165310C134018914 @default.
- W2024165310 hasConceptScore W2024165310C153911025 @default.
- W2024165310 hasConceptScore W2024165310C170493617 @default.
- W2024165310 hasConceptScore W2024165310C17991360 @default.
- W2024165310 hasConceptScore W2024165310C187345961 @default.
- W2024165310 hasConceptScore W2024165310C2776415932 @default.
- W2024165310 hasConceptScore W2024165310C2778150266 @default.
- W2024165310 hasConceptScore W2024165310C2779131090 @default.
- W2024165310 hasConceptScore W2024165310C2780091579 @default.
- W2024165310 hasConceptScore W2024165310C2780152017 @default.
- W2024165310 hasConceptScore W2024165310C55493867 @default.
- W2024165310 hasConceptScore W2024165310C71924100 @default.
- W2024165310 hasConceptScore W2024165310C85265743 @default.
- W2024165310 hasConceptScore W2024165310C86803240 @default.
- W2024165310 hasIssue "5" @default.
- W2024165310 hasLocation W20241653101 @default.
- W2024165310 hasLocation W20241653102 @default.
- W2024165310 hasOpenAccess W2024165310 @default.
- W2024165310 hasPrimaryLocation W20241653101 @default.
- W2024165310 hasRelatedWork W2009121312 @default.
- W2024165310 hasRelatedWork W2014113220 @default.
- W2024165310 hasRelatedWork W2068121938 @default.
- W2024165310 hasRelatedWork W2074466427 @default.
- W2024165310 hasRelatedWork W2108672863 @default.
- W2024165310 hasRelatedWork W2126085844 @default.
- W2024165310 hasRelatedWork W2126145245 @default.
- W2024165310 hasRelatedWork W2378681050 @default.
- W2024165310 hasRelatedWork W2990212168 @default.
- W2024165310 hasRelatedWork W4253699790 @default.
- W2024165310 hasVolume "26" @default.
- W2024165310 isParatext "false" @default.
- W2024165310 isRetracted "false" @default.
- W2024165310 magId "2024165310" @default.
- W2024165310 workType "article" @default.