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- W2024165792 abstract "DC not only activate CD4 T (Th) cell and cytotoxic CD8 T cell (CTL) responses against pathogens, but they also tolerize autoreactive T cells in order to avoid autoimmunity. Previous studies have demonstrated that steady-state DC can tolerize naïve CTL, naïve Th cells and memory CTL. A study in this issue of the European Journal of Immunology demonstrates that DC also tolerize memory Th cells. This is arguably most critical for developing therapies against autoimmune disease; first, because Th cells are the central regulators of all adaptive immune responses, and second because memory, rather than naïve T cells are the clinically relevant cells in established autoimmune diseases. This study fosters hope that DC-based specific immunotherapies for common autoimmune diseases are possible." @default.
- W2024165792 created "2016-06-24" @default.
- W2024165792 creator A5071291097 @default.
- W2024165792 date "2010-06-14" @default.
- W2024165792 modified "2023-09-25" @default.
- W2024165792 title "Dendritic cells erase bad memory" @default.
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- W2024165792 doi "https://doi.org/10.1002/eji.201040704" @default.
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