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• W2024166039 abstract "Background and Objectives:HMG-CoA reductase inhibitors have been used for a decade to lower LDL cholesterol levels and to improve cardiovascular diseases and clinical outcomes. This study was designed to ev- aluate the clinical efficacy and safety profiles of atorvastatin, a new HMG-CoA reductase inhibitor, in patients with elevated LDL-cholesterolemia. Material and Methods:Eighty three patients who had high 12-hour fasting serum LDL-cholesterol level (≥145 mg/dl and ≤250 mg/dl and serum TG level less than 400 mg/dl were enrolled. After completing an 4 week dietary phase, 50 patients who still had LDL-C ≥145 mg/dl and TG ≤400 mg/dl were assigned to receive atorvastatin 10 mg once daily for 4 weeks. After 4 weeks, the dose was continued for 4 weeks in each individual if serum LDL-cholesterol was maintained below 130 mg/dL. For each individual whose serum LDL-cholesterol was above 130 mg/dL, the dose was doubled (20 mg/day and administered for 4 weeks. Serum AST, ALT and CPK were also measured in addition to blood chemistry tests for lipid profiles at 4 and 8 weeks for safety assessment. Results:1 The total study population who completed the whole protocol was composed of 46 patients (23 male, 23 female, mean age 54 years. 2 At 4 weeks, the reduction by mean percent change from the baseline in LDL-cholesterol was -44.8% (from 182.3±3.4 mg/dl to 99.7±2.9 mg/dl. The fixed goal of LDL-cholesterol less than 130 mg/dl was achieved by 95.8%. 3 At 4 weeks, the mean percent change from the baseline in TC, TG, HDL-C, LDL/HDL-C and ApoB were -32.3%, -17.4%, +9.6%, -48.5% and -36.6%, respectively. 4 At 8 weeks, the mean percent change from the baseline in LDL-cholesterol was -43.0% (from 182.3±3.4 mg/dl to 103±2.4 mg/dl. The fixed goal of LDL-cholesterol less than 130 mg/dl was achieved by 91.3% of the whole patients. 5 At 8 weeks, the mean percent change from the baseline in TC, TG, HDL-C, LDL/HDL-C and ApoB were -31.3%, -22.6%, +13.7%, -48.8% and 논문접수일:1999년 7월 19일 심사완료일:1999년 11월 18일 교신저자:정남식 120-140 서울 서대문구 신촌동 134 연세대학교 의과대학 심장혈관센터 내과학교실 전화:(02 361-7071 / 7049・전송:(02 393-2041" @default.
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• W2024166039 date "1999-01-01" @default.
• W2024166039 modified "2023-09-26" @default.
• W2024166039 title "Efficacy and Safety of Atorvastatin in Patients with Elevated LDL-cholesterolemia" @default.
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• W2024166039 doi "https://doi.org/10.4070/kcj.1999.29.12.1309" @default.
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