FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024166144> ?p ?o ?g. }

• W2024166144 endingPage "292" @default.
• W2024166144 startingPage "286" @default.
• W2024166144 abstract "1. This study examines the relative contributions made by inhibition of mast cell degranulation, reduction of mast cell recruitment and maturation, and lowering the responsiveness of the vasculature to histamine, in the inhibition by glucocorticoids of the weal and flare in human skin. 2. One forearm of healthy human volunteers was treated for 24 h (n=6) or daily for 21 days (n=10) with 0.05% clobetasol propionate. The other arm served as control. Weal and flare responses were elicited by intradermal injection of 20 microl of 0.3 mM codeine. The areas of the responses were measured using scanning laser Doppler imaging. Microdialysis was used to assess histamine release. Mast cell numbers and tissue histamine content were assessed in 4-mm punch biopsies. Histamine (20 microl of 1 microM i.d.) was used to assess the status of the vasculature. 3. No significant effects were seen at 24 h. At 21 days, clobetasol reduced the areas of the codeine-induced weal and flare responses by 59 and 58% respectively (both P=0.006). Mast cell numbers were reduced by 47%, (P=0.014) and total tissue histamine content by 52% (P=0.006). Codeine-induced histamine release was reduced by 44% (P=0.022). The weal, but not the flare, induced by histamine was significantly inhibited (P=0.019). Echography revealed a 15% thinning of the skin by clobetasol. 4. These results demonstrate that reduction of the weal and flare responses to codeine following clobetasol treatment, results primarily from reduced mast cell numbers and tissue histamine content rather than inhibition by corticosteroids of mast cell degranulation." @default.
• W2024166144 created "2016-06-24" @default.
• W2024166144 creator A5005311406 @default.
• W2024166144 creator A5035800000 @default.
• W2024166144 creator A5089100867 @default.
• W2024166144 date "2001-01-01" @default.
• W2024166144 modified "2023-10-18" @default.
• W2024166144 title "Inhibition by glucocorticoids of the mast cell-dependent weal and flare response in human skin<i>in vivo</i>" @default.
• W2024166144 cites W1538514298 @default.
• W2024166144 cites W1545432734 @default.
• W2024166144 cites W1555685181 @default.
• W2024166144 cites W1664567304 @default.
• W2024166144 cites W1745264954 @default.
• W2024166144 cites W1917870859 @default.
• W2024166144 cites W1925993153 @default.
• W2024166144 cites W1966679154 @default.
• W2024166144 cites W1969923896 @default.
• W2024166144 cites W1975821708 @default.
• W2024166144 cites W1976480241 @default.
• W2024166144 cites W1980921404 @default.
• W2024166144 cites W1987676457 @default.
• W2024166144 cites W1993287709 @default.
• W2024166144 cites W2000415265 @default.
• W2024166144 cites W2025615143 @default.
• W2024166144 cites W2030081496 @default.
• W2024166144 cites W2033465310 @default.
• W2024166144 cites W2037459469 @default.
• W2024166144 cites W2040514575 @default.
• W2024166144 cites W2040634115 @default.
• W2024166144 cites W2042257787 @default.
• W2024166144 cites W2047558967 @default.
• W2024166144 cites W2062655011 @default.
• W2024166144 cites W2067410717 @default.
• W2024166144 cites W2081397692 @default.
• W2024166144 cites W2086870314 @default.
• W2024166144 cites W2088310945 @default.
• W2024166144 cites W2107063265 @default.
• W2024166144 cites W2126592321 @default.
• W2024166144 cites W2139644186 @default.
• W2024166144 cites W2141716446 @default.
• W2024166144 cites W2151482480 @default.
• W2024166144 cites W2331176038 @default.
• W2024166144 cites W2331508609 @default.
• W2024166144 cites W2429656160 @default.
• W2024166144 cites W2465960448 @default.
• W2024166144 cites W4241821473 @default.
• W2024166144 doi "https://doi.org/10.1038/sj.bjp.0703789" @default.
• W2024166144 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1572547" @default.
• W2024166144 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11156588" @default.
• W2024166144 hasPublicationYear "2001" @default.
• W2024166144 type Work @default.
• W2024166144 sameAs 2024166144 @default.
• W2024166144 citedByCount "23" @default.
• W2024166144 countsByYear W20241661442012 @default.
• W2024166144 countsByYear W20241661442014 @default.
• W2024166144 countsByYear W20241661442016 @default.
• W2024166144 countsByYear W20241661442017 @default.
• W2024166144 countsByYear W20241661442018 @default.
• W2024166144 countsByYear W20241661442019 @default.
• W2024166144 countsByYear W20241661442021 @default.
• W2024166144 countsByYear W20241661442022 @default.
• W2024166144 countsByYear W20241661442023 @default.
• W2024166144 crossrefType "journal-article" @default.
• W2024166144 hasAuthorship W2024166144A5005311406 @default.
• W2024166144 hasAuthorship W2024166144A5035800000 @default.
• W2024166144 hasAuthorship W2024166144A5089100867 @default.
• W2024166144 hasBestOaLocation W20241661442 @default.
• W2024166144 hasConcept C1122143 @default.
• W2024166144 hasConcept C126322002 @default.
• W2024166144 hasConcept C134018914 @default.
• W2024166144 hasConcept C142724271 @default.
• W2024166144 hasConcept C150903083 @default.
• W2024166144 hasConcept C170493617 @default.
• W2024166144 hasConcept C185592680 @default.
• W2024166144 hasConcept C203014093 @default.
• W2024166144 hasConcept C207001950 @default.
• W2024166144 hasConcept C2777459323 @default.
• W2024166144 hasConcept C2777624698 @default.
• W2024166144 hasConcept C2778937273 @default.
• W2024166144 hasConcept C2779726688 @default.
• W2024166144 hasConcept C49802076 @default.
• W2024166144 hasConcept C50156730 @default.
• W2024166144 hasConcept C54355233 @default.
• W2024166144 hasConcept C71924100 @default.
• W2024166144 hasConcept C86803240 @default.
• W2024166144 hasConcept C98274493 @default.
• W2024166144 hasConceptScore W2024166144C1122143 @default.
• W2024166144 hasConceptScore W2024166144C126322002 @default.
• W2024166144 hasConceptScore W2024166144C134018914 @default.
• W2024166144 hasConceptScore W2024166144C142724271 @default.
• W2024166144 hasConceptScore W2024166144C150903083 @default.
• W2024166144 hasConceptScore W2024166144C170493617 @default.
• W2024166144 hasConceptScore W2024166144C185592680 @default.
• W2024166144 hasConceptScore W2024166144C203014093 @default.
• W2024166144 hasConceptScore W2024166144C207001950 @default.
• W2024166144 hasConceptScore W2024166144C2777459323 @default.
• W2024166144 hasConceptScore W2024166144C2777624698 @default.
• W2024166144 hasConceptScore W2024166144C2778937273 @default.

• next