FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024166544> ?p ?o ?g. }

• W2024166544 endingPage "634" @default.
• W2024166544 startingPage "625" @default.
• W2024166544 abstract "We analyzed how cells from tumors caused by mutations in either lgl or brat use matrix metalloproteinases (MMPs) to facilitate metastasis in Drosophila. MMP1 accumulation is dramatically increased in lgl larval imaginal discs compared to both wild type and brat mutants. Removal of Mmp1 gene activity in lgl brain tumor cells reduced their frequency of ovarian micro-metastases after transplantation; whereas, removal of Mmp1 gene activity in brat tumor cells had no such effect. Host ovaries showed increased Mmp1 gene expression in response to transplantation of brat tumors but not of lgl tumors. Reduction of MMP activity in host ovaries by ectopic expression of TIMP significantly reduced both lgl and brat metastases in that organ. These results highlight the mechanisms that lgl and brat tumor cells use to metastasize. Our interpretation of these data is that secretion of MMP1 from lgl tumor cells facilitates their metastasis, while secretion of MMP1 from host ovaries facilitates brat tumor metastasis. This study is the first demonstration that Drosophila tumors utilize MMP activity to metastasize." @default.
• W2024166544 created "2016-06-24" @default.
• W2024166544 creator A5014808968 @default.
• W2024166544 creator A5057285777 @default.
• W2024166544 creator A5062092111 @default.
• W2024166544 creator A5076430544 @default.
• W2024166544 date "2007-03-01" @default.
• W2024166544 modified "2023-10-06" @default.
• W2024166544 title "Metastatic ability of Drosophila tumors depends on MMP activity" @default.
• W2024166544 cites W1656339735 @default.
• W2024166544 cites W1973017365 @default.
• W2024166544 cites W1976831807 @default.
• W2024166544 cites W1978769760 @default.
• W2024166544 cites W1979476810 @default.
• W2024166544 cites W1981828489 @default.
• W2024166544 cites W1982036031 @default.
• W2024166544 cites W1986193436 @default.
• W2024166544 cites W1993115402 @default.
• W2024166544 cites W2002450099 @default.
• W2024166544 cites W2002602524 @default.
• W2024166544 cites W2005113904 @default.
• W2024166544 cites W2005435457 @default.
• W2024166544 cites W2007503777 @default.
• W2024166544 cites W2010715204 @default.
• W2024166544 cites W2049820772 @default.
• W2024166544 cites W2056802402 @default.
• W2024166544 cites W2058703787 @default.
• W2024166544 cites W2071507111 @default.
• W2024166544 cites W2074187493 @default.
• W2024166544 cites W2092743430 @default.
• W2024166544 cites W2102735676 @default.
• W2024166544 cites W2107691721 @default.
• W2024166544 cites W2110204757 @default.
• W2024166544 cites W2116305904 @default.
• W2024166544 cites W2123905405 @default.
• W2024166544 cites W2128049766 @default.
• W2024166544 cites W2141592196 @default.
• W2024166544 cites W2156085478 @default.
• W2024166544 cites W2160680240 @default.
• W2024166544 cites W2161998309 @default.
• W2024166544 cites W4245042014 @default.
• W2024166544 cites W4255941290 @default.
• W2024166544 cites W4376848667 @default.
• W2024166544 doi "https://doi.org/10.1016/j.ydbio.2006.12.001" @default.
• W2024166544 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17239363" @default.
• W2024166544 hasPublicationYear "2007" @default.
• W2024166544 type Work @default.
• W2024166544 sameAs 2024166544 @default.
• W2024166544 citedByCount "89" @default.
• W2024166544 countsByYear W20241665442012 @default.
• W2024166544 countsByYear W20241665442013 @default.
• W2024166544 countsByYear W20241665442014 @default.
• W2024166544 countsByYear W20241665442015 @default.
• W2024166544 countsByYear W20241665442016 @default.
• W2024166544 countsByYear W20241665442017 @default.
• W2024166544 countsByYear W20241665442018 @default.
• W2024166544 countsByYear W20241665442019 @default.
• W2024166544 countsByYear W20241665442020 @default.
• W2024166544 countsByYear W20241665442021 @default.
• W2024166544 countsByYear W20241665442022 @default.
• W2024166544 countsByYear W20241665442023 @default.
• W2024166544 crossrefType "journal-article" @default.
• W2024166544 hasAuthorship W2024166544A5014808968 @default.
• W2024166544 hasAuthorship W2024166544A5057285777 @default.
• W2024166544 hasAuthorship W2024166544A5062092111 @default.
• W2024166544 hasAuthorship W2024166544A5076430544 @default.
• W2024166544 hasBestOaLocation W20241665441 @default.
• W2024166544 hasConcept C104317684 @default.
• W2024166544 hasConcept C109523444 @default.
• W2024166544 hasConcept C121608353 @default.
• W2024166544 hasConcept C126322002 @default.
• W2024166544 hasConcept C129527566 @default.
• W2024166544 hasConcept C142724271 @default.
• W2024166544 hasConcept C150194340 @default.
• W2024166544 hasConcept C2779013556 @default.
• W2024166544 hasConcept C2911091166 @default.
• W2024166544 hasConcept C502942594 @default.
• W2024166544 hasConcept C54355233 @default.
• W2024166544 hasConcept C71924100 @default.
• W2024166544 hasConcept C86803240 @default.
• W2024166544 hasConceptScore W2024166544C104317684 @default.
• W2024166544 hasConceptScore W2024166544C109523444 @default.
• W2024166544 hasConceptScore W2024166544C121608353 @default.
• W2024166544 hasConceptScore W2024166544C126322002 @default.
• W2024166544 hasConceptScore W2024166544C129527566 @default.
• W2024166544 hasConceptScore W2024166544C142724271 @default.
• W2024166544 hasConceptScore W2024166544C150194340 @default.
• W2024166544 hasConceptScore W2024166544C2779013556 @default.
• W2024166544 hasConceptScore W2024166544C2911091166 @default.
• W2024166544 hasConceptScore W2024166544C502942594 @default.
• W2024166544 hasConceptScore W2024166544C54355233 @default.
• W2024166544 hasConceptScore W2024166544C71924100 @default.
• W2024166544 hasConceptScore W2024166544C86803240 @default.
• W2024166544 hasIssue "2" @default.
• W2024166544 hasLocation W20241665441 @default.
• W2024166544 hasLocation W20241665442 @default.
• W2024166544 hasOpenAccess W2024166544 @default.
• W2024166544 hasPrimaryLocation W20241665441 @default.

• next