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- W2024169795 abstract "Transcription of the early gametocyte-specific gene pfg2725, and genomic structure and polymorphism of its upstream region were studied in the human malaria parasite Plasmodium falciparum. The upstream genomic sequence of the pfg2725 gene is characterised by a repetitive region that contains five direct and one inverted repeats of a unit constituted by a perfectly conserved sequence flanked by a poly-dT and a poly-d(AT) tract. Sequences further upstream from the repetitive region are polymorphic in distantly related parasite lines. Nuclear ‘run off’ experiments indicated that transcription of pfg2725 is developmentally regulated. Transcription of the gene, undetectable in asexual parasites, is activated at the onset of gametocytogenesis. The gene is transcribed in a 2.5 kb mature mRNA for the first 2–3 days of sexual differentiation, while transcription is down-regulated in more mature gametocytes." @default.
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- W2024169795 date "1996-08-01" @default.
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- W2024169795 title "Structure and polymorphism of the upstream region of the pfg2725 gene, transcriptionally regulated in gametocytogenesis of Plasmodium falciparum" @default.
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- W2024169795 doi "https://doi.org/10.1016/0166-6851(96)02663-1" @default.
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