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- W2024172725 endingPage "978" @default.
- W2024172725 startingPage "967" @default.
- W2024172725 abstract "Heme proteins play a major role in various biological functions, such as oxygen sensing, electron transport, signal transduction, and antioxidant defense enzymes. Most of these reactions are carried out by redox reactions of heme iron. As the heme is not recycled, most cells containing heme proteins have the microsomal mixed function oxygenase, heme oxygenase, which enzymatically degrades heme to biliverdin, carbon monoxide, and iron. However, the red cell with the largest pool of heme protein, hemoglobin, contains no heme oxygenase, and enzymatic degradation of the red cell heme occurs only after the senescent red cells are removed by the reticuloendothelial system. Therefore, only nonenzymatic heme degradation initiated when the heme iron undergoes redox reactions in the presence of oxygen-producing reactive oxygen species takes place in the red cell. Unlike enzymatic degradation, which specifically attacks the α-methene bridge, reactive oxygen species randomly attack all the carbon methene bridges of the tetrapyrrole rings, producing various pyrrole products in addition to releasing iron. This review focuses on the literature related to nonenzymatic heme degradation with special emphasis on hemoglobin, the dominant red cell heme protein. Antioxid. Redox Signal. 6, 967–978." @default.
- W2024172725 created "2016-06-24" @default.
- W2024172725 creator A5001330490 @default.
- W2024172725 creator A5021365260 @default.
- W2024172725 date "2004-12-01" @default.
- W2024172725 modified "2023-10-12" @default.
- W2024172725 title "Heme Degradation by Reactive Oxygen Species" @default.
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- W2024172725 doi "https://doi.org/10.1089/ars.2004.6.967" @default.
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