Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024173718> ?p ?o ?g. }
- W2024173718 endingPage "237" @default.
- W2024173718 startingPage "221" @default.
- W2024173718 abstract "Nuclear receptors (NRs) are major pharmacological targets that allow an access to the mechanisms controlling gene regulation. As such, some NRs were identified as biological targets of active compounds contained in herbal remedies found in traditional medicines. We aim here to review this expanding literature by focusing on the informative articles regarding the mechanisms of action of traditional Chinese medicines (TCMs). We exemplified well-characterized TCM action mediated by NR such as steroid receptors (ER, GR, AR), metabolic receptors (PPAR, LXR, FXR, PXR, CAR) and RXR. We also provided, when possible, examples from other traditional medicines. From these, we draw a parallel between TCMs and phytoestrogens or endocrine disrupting chemicals also acting via NR. We define common principle of action and highlight the potential and limits of those compounds. TCMs, by finely tuning physiological reactions in positive and negative manners, could act, in a subtle but efficient way, on NR sensors and their transcriptional network." @default.
- W2024173718 created "2016-06-24" @default.
- W2024173718 creator A5040893929 @default.
- W2024173718 creator A5063414474 @default.
- W2024173718 creator A5065897303 @default.
- W2024173718 creator A5089653205 @default.
- W2024173718 date "2015-02-01" @default.
- W2024173718 modified "2023-10-16" @default.
- W2024173718 title "Botanical compounds and their regulation of nuclear receptor action: The case of traditional Chinese medicine" @default.
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