FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024174916> ?p ?o ?g. }

• W2024174916 endingPage "4413" @default.
• W2024174916 startingPage "4404" @default.
• W2024174916 abstract "Femtosecond coherence spectroscopy is used to probe low frequency (20–400 cm−1) modes of the ferrous heme group in solution, with and without 2-methyl imidazole (2MeIm) as an axial ligand. The results are compared to heme proteins (CPO, P450cam, HRP, Mb) where insertion of the heme into the protein results in redistribution of the low frequency spectral density and in (∼60%) longer damping times for the coherent signals. The major effect of imidazole ligation to the ferrous heme is the “softening” of the low frequency force constants by a factor of ∼0.6 ± 0.1. The functional consequences of imidazole ligation are assessed and it is found that the enthalpic CO rebinding barrier is increased significantly when imidazole is bound. The force constant softening analysis, combined with the kinetics results, indicates that the iron is displaced by only ∼0.2 Å from the heme plane in the absence of the imidazole ligand, whereas it is displaced by ∼0.4 Å when imidazole (histidine) is present. This suggests that binding of imidazole (histidine) as an axial ligand, and the concomitant softening of the force constants, leads to an anharmonic distortion of the heme group that has significant functional consequences." @default.
• W2024174916 created "2016-06-24" @default.
• W2024174916 creator A5032679339 @default.
• W2024174916 creator A5039846510 @default.
• W2024174916 creator A5049580087 @default.
• W2024174916 creator A5055941514 @default.
• W2024174916 creator A5063140842 @default.
• W2024174916 date "2007-12-01" @default.
• W2024174916 modified "2023-10-15" @default.
• W2024174916 title "Low Frequency Spectral Density of Ferrous Heme: Perturbations Induced by Axial Ligation and Protein Insertion" @default.
• W2024174916 cites W1601593267 @default.
• W2024174916 cites W1967631785 @default.
• W2024174916 cites W1967686739 @default.
• W2024174916 cites W1967931058 @default.
• W2024174916 cites W1974392663 @default.
• W2024174916 cites W1976198638 @default.
• W2024174916 cites W1976404178 @default.
• W2024174916 cites W1977925810 @default.
• W2024174916 cites W1978862989 @default.
• W2024174916 cites W1982104189 @default.
• W2024174916 cites W1983593861 @default.
• W2024174916 cites W1984775938 @default.
• W2024174916 cites W1985712992 @default.
• W2024174916 cites W1990867492 @default.
• W2024174916 cites W1991448612 @default.
• W2024174916 cites W1991775490 @default.
• W2024174916 cites W1993819395 @default.
• W2024174916 cites W1995352868 @default.
• W2024174916 cites W1995579078 @default.
• W2024174916 cites W2009042689 @default.
• W2024174916 cites W2010899620 @default.
• W2024174916 cites W2011289735 @default.
• W2024174916 cites W2011892644 @default.
• W2024174916 cites W2013620075 @default.
• W2024174916 cites W2015258215 @default.
• W2024174916 cites W2019688079 @default.
• W2024174916 cites W2022944892 @default.
• W2024174916 cites W2023876126 @default.
• W2024174916 cites W2028630092 @default.
• W2024174916 cites W2029990433 @default.
• W2024174916 cites W2032372720 @default.
• W2024174916 cites W2036136843 @default.
• W2024174916 cites W2039247008 @default.
• W2024174916 cites W2042676452 @default.
• W2024174916 cites W2046219984 @default.
• W2024174916 cites W2048915730 @default.
• W2024174916 cites W2049212026 @default.
• W2024174916 cites W2051438976 @default.
• W2024174916 cites W2062415830 @default.
• W2024174916 cites W2062957444 @default.
• W2024174916 cites W2064850136 @default.
• W2024174916 cites W2070790598 @default.
• W2024174916 cites W2074187763 @default.
• W2024174916 cites W2075333740 @default.
• W2024174916 cites W2078093171 @default.
• W2024174916 cites W2085200792 @default.
• W2024174916 cites W2087075174 @default.
• W2024174916 cites W2117758787 @default.
• W2024174916 cites W2144757756 @default.
• W2024174916 cites W2154251984 @default.
• W2024174916 cites W2166218211 @default.
• W2024174916 cites W2173306066 @default.
• W2024174916 doi "https://doi.org/10.1529/biophysj.107.114736" @default.
• W2024174916 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2098722" @default.
• W2024174916 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17766351" @default.
• W2024174916 hasPublicationYear "2007" @default.
• W2024174916 type Work @default.
• W2024174916 sameAs 2024174916 @default.
• W2024174916 citedByCount "22" @default.
• W2024174916 countsByYear W20241749162012 @default.
• W2024174916 countsByYear W20241749162013 @default.
• W2024174916 countsByYear W20241749162014 @default.
• W2024174916 countsByYear W20241749162016 @default.
• W2024174916 countsByYear W20241749162017 @default.
• W2024174916 countsByYear W20241749162018 @default.
• W2024174916 countsByYear W20241749162019 @default.
• W2024174916 countsByYear W20241749162020 @default.
• W2024174916 countsByYear W20241749162021 @default.
• W2024174916 countsByYear W20241749162023 @default.
• W2024174916 crossrefType "journal-article" @default.
• W2024174916 hasAuthorship W2024174916A5032679339 @default.
• W2024174916 hasAuthorship W2024174916A5039846510 @default.
• W2024174916 hasAuthorship W2024174916A5049580087 @default.
• W2024174916 hasAuthorship W2024174916A5055941514 @default.
• W2024174916 hasAuthorship W2024174916A5063140842 @default.
• W2024174916 hasBestOaLocation W20241749161 @default.
• W2024174916 hasConcept C116569031 @default.
• W2024174916 hasConcept C121332964 @default.
• W2024174916 hasConcept C159985019 @default.
• W2024174916 hasConcept C170493617 @default.
• W2024174916 hasConcept C178790620 @default.
• W2024174916 hasConcept C181199279 @default.
• W2024174916 hasConcept C185592680 @default.
• W2024174916 hasConcept C192562407 @default.
• W2024174916 hasConcept C20705724 @default.
• W2024174916 hasConcept C2775832776 @default.
• W2024174916 hasConcept C2776217839 @default.
• W2024174916 hasConcept C2778063876 @default.

• next