Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024175600> ?p ?o ?g. }
- W2024175600 abstract "The tight interaction between genomic DNA and histones, which normally represses gene transcription, can be relaxed by histone acetylation. This loosening of the DNA-histone complex is important for selective gene activation during stem cell differentiation. Histone acetylation may be increased through the application of histone deacetylase inhibitors at the early stages of differentiation to modulate lineage commitment. We examined the effects of the histone deacetylase inhibitor valproic acid on the differentiation of pluripotent stem cells into skeletal myocytes. Our data demonstrated that valproic acid can act in concert with retinoic acid to enhance the commitment of stem cells into the skeletal myocyte lineage reinforcing the notion that histone acetylation is important for skeletal myogenesis. Thus, using a combination of small molecules to exploit different signaling pathways pertaining to specific gene programs will allow for modulation of lineage specification and stem cell differentiation in potential cell-based therapies." @default.
- W2024175600 created "2016-06-24" @default.
- W2024175600 creator A5021623991 @default.
- W2024175600 creator A5052845882 @default.
- W2024175600 creator A5078384114 @default.
- W2024175600 date "2014-11-26" @default.
- W2024175600 modified "2023-09-23" @default.
- W2024175600 title "Effects of histone deacetylase inhibitor valproic acid on skeletal myocyte development" @default.
- W2024175600 cites W1826748661 @default.
- W2024175600 cites W1993126060 @default.
- W2024175600 cites W1993712190 @default.
- W2024175600 cites W1995032020 @default.
- W2024175600 cites W1995731089 @default.
- W2024175600 cites W2002698073 @default.
- W2024175600 cites W2006131488 @default.
- W2024175600 cites W2011656809 @default.
- W2024175600 cites W2026237709 @default.
- W2024175600 cites W2029078015 @default.
- W2024175600 cites W2033103604 @default.
- W2024175600 cites W2033357192 @default.
- W2024175600 cites W2033926629 @default.
- W2024175600 cites W2034759240 @default.
- W2024175600 cites W2035631829 @default.
- W2024175600 cites W2060381038 @default.
- W2024175600 cites W2081178187 @default.
- W2024175600 cites W2083441653 @default.
- W2024175600 cites W2094339263 @default.
- W2024175600 cites W2098249941 @default.
- W2024175600 cites W2106775330 @default.
- W2024175600 cites W2110567017 @default.
- W2024175600 cites W2112485709 @default.
- W2024175600 cites W2119558650 @default.
- W2024175600 cites W2144509907 @default.
- W2024175600 cites W2151754128 @default.
- W2024175600 cites W2159887704 @default.
- W2024175600 cites W2165296692 @default.
- W2024175600 doi "https://doi.org/10.1038/srep07207" @default.
- W2024175600 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4244627" @default.
- W2024175600 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25423891" @default.
- W2024175600 hasPublicationYear "2014" @default.
- W2024175600 type Work @default.
- W2024175600 sameAs 2024175600 @default.
- W2024175600 citedByCount "14" @default.
- W2024175600 countsByYear W20241756002016 @default.
- W2024175600 countsByYear W20241756002017 @default.
- W2024175600 countsByYear W20241756002018 @default.
- W2024175600 countsByYear W20241756002019 @default.
- W2024175600 countsByYear W20241756002020 @default.
- W2024175600 countsByYear W20241756002021 @default.
- W2024175600 countsByYear W20241756002022 @default.
- W2024175600 crossrefType "journal-article" @default.
- W2024175600 hasAuthorship W2024175600A5021623991 @default.
- W2024175600 hasAuthorship W2024175600A5052845882 @default.
- W2024175600 hasAuthorship W2024175600A5078384114 @default.
- W2024175600 hasBestOaLocation W20241756001 @default.
- W2024175600 hasConcept C104317684 @default.
- W2024175600 hasConcept C119157956 @default.
- W2024175600 hasConcept C148738053 @default.
- W2024175600 hasConcept C185592680 @default.
- W2024175600 hasConcept C27253355 @default.
- W2024175600 hasConcept C2776202225 @default.
- W2024175600 hasConcept C2778305200 @default.
- W2024175600 hasConcept C45946802 @default.
- W2024175600 hasConcept C4951695 @default.
- W2024175600 hasConcept C55493867 @default.
- W2024175600 hasConcept C58793620 @default.
- W2024175600 hasConcept C64927066 @default.
- W2024175600 hasConcept C71723506 @default.
- W2024175600 hasConcept C86803240 @default.
- W2024175600 hasConcept C95444343 @default.
- W2024175600 hasConceptScore W2024175600C104317684 @default.
- W2024175600 hasConceptScore W2024175600C119157956 @default.
- W2024175600 hasConceptScore W2024175600C148738053 @default.
- W2024175600 hasConceptScore W2024175600C185592680 @default.
- W2024175600 hasConceptScore W2024175600C27253355 @default.
- W2024175600 hasConceptScore W2024175600C2776202225 @default.
- W2024175600 hasConceptScore W2024175600C2778305200 @default.
- W2024175600 hasConceptScore W2024175600C45946802 @default.
- W2024175600 hasConceptScore W2024175600C4951695 @default.
- W2024175600 hasConceptScore W2024175600C55493867 @default.
- W2024175600 hasConceptScore W2024175600C58793620 @default.
- W2024175600 hasConceptScore W2024175600C64927066 @default.
- W2024175600 hasConceptScore W2024175600C71723506 @default.
- W2024175600 hasConceptScore W2024175600C86803240 @default.
- W2024175600 hasConceptScore W2024175600C95444343 @default.
- W2024175600 hasIssue "1" @default.
- W2024175600 hasLocation W20241756001 @default.
- W2024175600 hasLocation W20241756002 @default.
- W2024175600 hasLocation W20241756003 @default.
- W2024175600 hasLocation W20241756004 @default.
- W2024175600 hasOpenAccess W2024175600 @default.
- W2024175600 hasPrimaryLocation W20241756001 @default.
- W2024175600 hasRelatedWork W1971370053 @default.
- W2024175600 hasRelatedWork W2038568403 @default.
- W2024175600 hasRelatedWork W2056711185 @default.
- W2024175600 hasRelatedWork W2088233020 @default.
- W2024175600 hasRelatedWork W2123257716 @default.
- W2024175600 hasRelatedWork W2369112976 @default.
- W2024175600 hasRelatedWork W2791494815 @default.
- W2024175600 hasRelatedWork W3032644962 @default.