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- W2024175809 abstract "The production of fully immunologically competent humanized mice engrafted with peripheral lymphocyte populations provides a model for in vivo testing of new vaccines, the durability of immunological memory and cancer therapies. This approach is limited, however, by the failure to efficiently engraft human B lymphocytes in immunodeficient mice. We hypothesized that this deficiency was due to the failure of the murine microenvironment to support human B cell survival. We report that while the human B lymphocyte survival factor, B lymphocyte stimulator (BLyS/BAFF) enhances the survival of human B cells ex vivo, murine BLyS has no such protective effect. Although human B cells bound both human and murine BLyS, nuclear accumulation of NF-kappaB p52, an indication of the induction of a protective anti-apoptotic response, following stimulation with human BLyS was more robust than that induced with murine BLyS suggesting a fundamental disparity in BLyS receptor signaling. Efficient engraftment of both human B and T lymphocytes in NOD rag1(-/-) Prf1(-/-) immunodeficient mice treated with recombinant human BLyS is observed after adoptive transfer of human PBL relative to PBS treated controls. Human BLyS treated recipients had on average 40-fold higher levels of serum Ig than controls and mounted a de novo antibody response to the thymus-independent antigens in pneumovax vaccine. The data indicate that production of fully immunologically competent humanized mice from PBL can be markedly facilitated by providing human BLyS." @default.
- W2024175809 created "2016-06-24" @default.
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- W2024175809 creator A5079134164 @default.
- W2024175809 date "2008-09-11" @default.
- W2024175809 modified "2023-10-12" @default.
- W2024175809 title "Human BLyS Facilitates Engraftment of Human PBL Derived B Cells in Immunodeficient Mice" @default.
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- W2024175809 doi "https://doi.org/10.1371/journal.pone.0003192" @default.
- W2024175809 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2527131" @default.
- W2024175809 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18784835" @default.
- W2024175809 hasPublicationYear "2008" @default.
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