FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024176002> ?p ?o ?g. }

• W2024176002 abstract "Background: A recent study has shown that proton pump inhibitor (PPI) therapy induces acid-related symptoms in healthy volunteers after PPI withdrawal. Rebound acid hypersecretion (RAHS) is believed to arise from the trophic effects of the PPI-induced hypergastrinemia on the oxyntic mucosa, lasting 4-8 weeks after discontinuing the PPI therapy. Aims: To assess whether PPI withdrawal may exacerbate reflux symptoms and increase esophageal acid exposure in patients with gastroesophageal reflux disease (GERD). Methods: Patients consecutively investigated for GERD with a validated symptoms questionnaire and 24h pH monitoring off PPI had their data revised from a prospectively constructed database. Heartburn and regurgitation in the last week before pH monitoring were scored between 0 (no symptom) and 5 (worst). GERD was defined according to Montreal criteria. Patients were classified as “naive to PPI therapy” (group 1) or “studied after discontinuing regular use of PPI”, which were reclassified according to the interval in days between PPI withdrawal and pH monitoring: 7-10 (group 2), 11-20 (group 3), and 21-90 (group 4). Results: Among 329 patients investigated for GERD (age 47 ± 15 years, 64% women, BMI 26 ± 3.8 kg/m2), those who discontinued PPI either between 7-10 days or 11-20 days scored higher for symptoms than groups 1 (naive to PPI, P < 0.001) and 4 (21-90 days, P < 0.05). Acid exposure was higher only in patients who discontinued PPI between 11-20 days, in comparison with groups 1 (naive do PPI, P < 0.05) and 4 (21-90 days, P < 0.01). When analyzing GERD patients (n = 249, figure), those who discontinued PPI between 7-10 days scored higher for symptoms compared to groups 1 and 4, whereas acid exposure was higher only in patients evaluated after 11-20 days of PPI withdrawal. Conclusions: This study suggests that PPI withdrawal may exacerbate reflux symptoms and increase acid exposure in patients with GERD. Symptoms were more remarkable soon after (7-10 days) discontinuation of PPI, whereas increased acid reflux had a later peak at 11-20 days, followed by attenuation of both symptoms and acid exposure. Whether these findings are related with a sequence of events starting with RAHS and ending with a protective response of the esophagus needs to be addressed." @default.
• W2024176002 created "2016-06-24" @default.
• W2024176002 creator A5018653096 @default.
• W2024176002 creator A5029930183 @default.
• W2024176002 creator A5042544807 @default.
• W2024176002 creator A5063884387 @default.
• W2024176002 date "2010-05-01" @default.
• W2024176002 modified "2023-09-26" @default.
• W2024176002 title "W1117 Influence of CYP2C19 Polymorphism on Lansoprazole and Rabeprazole Maintenance Treatment of Reflux Esophagitis" @default.
• W2024176002 doi "https://doi.org/10.1016/s0016-5085(10)63013-2" @default.
• W2024176002 hasPublicationYear "2010" @default.
• W2024176002 type Work @default.
• W2024176002 sameAs 2024176002 @default.
• W2024176002 citedByCount "0" @default.
• W2024176002 crossrefType "journal-article" @default.
• W2024176002 hasAuthorship W2024176002A5018653096 @default.
• W2024176002 hasAuthorship W2024176002A5029930183 @default.
• W2024176002 hasAuthorship W2024176002A5042544807 @default.
• W2024176002 hasAuthorship W2024176002A5063884387 @default.
• W2024176002 hasConcept C126322002 @default.
• W2024176002 hasConcept C140840227 @default.
• W2024176002 hasConcept C2776462128 @default.
• W2024176002 hasConcept C2777014526 @default.
• W2024176002 hasConcept C2777498785 @default.
• W2024176002 hasConcept C2777504413 @default.
• W2024176002 hasConcept C2777683962 @default.
• W2024176002 hasConcept C2778715759 @default.
• W2024176002 hasConcept C2779116819 @default.
• W2024176002 hasConcept C2779134260 @default.
• W2024176002 hasConcept C2779422922 @default.
• W2024176002 hasConcept C2779920096 @default.
• W2024176002 hasConcept C2779949763 @default.
• W2024176002 hasConcept C2781025758 @default.
• W2024176002 hasConcept C2909576783 @default.
• W2024176002 hasConcept C43270747 @default.
• W2024176002 hasConcept C526171541 @default.
• W2024176002 hasConcept C62231903 @default.
• W2024176002 hasConcept C71924100 @default.
• W2024176002 hasConcept C90924648 @default.
• W2024176002 hasConceptScore W2024176002C126322002 @default.
• W2024176002 hasConceptScore W2024176002C140840227 @default.
• W2024176002 hasConceptScore W2024176002C2776462128 @default.
• W2024176002 hasConceptScore W2024176002C2777014526 @default.
• W2024176002 hasConceptScore W2024176002C2777498785 @default.
• W2024176002 hasConceptScore W2024176002C2777504413 @default.
• W2024176002 hasConceptScore W2024176002C2777683962 @default.
• W2024176002 hasConceptScore W2024176002C2778715759 @default.
• W2024176002 hasConceptScore W2024176002C2779116819 @default.
• W2024176002 hasConceptScore W2024176002C2779134260 @default.
• W2024176002 hasConceptScore W2024176002C2779422922 @default.
• W2024176002 hasConceptScore W2024176002C2779920096 @default.
• W2024176002 hasConceptScore W2024176002C2779949763 @default.
• W2024176002 hasConceptScore W2024176002C2781025758 @default.
• W2024176002 hasConceptScore W2024176002C2909576783 @default.
• W2024176002 hasConceptScore W2024176002C43270747 @default.
• W2024176002 hasConceptScore W2024176002C526171541 @default.
• W2024176002 hasConceptScore W2024176002C62231903 @default.
• W2024176002 hasConceptScore W2024176002C71924100 @default.
• W2024176002 hasConceptScore W2024176002C90924648 @default.
• W2024176002 hasLocation W20241760021 @default.
• W2024176002 hasOpenAccess W2024176002 @default.
• W2024176002 hasPrimaryLocation W20241760021 @default.
• W2024176002 hasRelatedWork W1541562199 @default.
• W2024176002 hasRelatedWork W1963661468 @default.
• W2024176002 hasRelatedWork W2020236739 @default.
• W2024176002 hasRelatedWork W2041373261 @default.
• W2024176002 hasRelatedWork W2164584759 @default.
• W2024176002 hasRelatedWork W2331977130 @default.
• W2024176002 hasRelatedWork W2401549125 @default.
• W2024176002 hasRelatedWork W2738903383 @default.
• W2024176002 hasRelatedWork W2743119641 @default.
• W2024176002 hasRelatedWork W2794663694 @default.
• W2024176002 hasRelatedWork W2809021076 @default.
• W2024176002 hasRelatedWork W2944324594 @default.
• W2024176002 hasRelatedWork W2984257373 @default.
• W2024176002 hasRelatedWork W3002109923 @default.
• W2024176002 hasRelatedWork W3004585965 @default.
• W2024176002 hasRelatedWork W3029105323 @default.
• W2024176002 hasRelatedWork W3046766815 @default.
• W2024176002 hasRelatedWork W3085508902 @default.
• W2024176002 hasRelatedWork W3110752413 @default.
• W2024176002 hasRelatedWork W3183240331 @default.
• W2024176002 isParatext "false" @default.
• W2024176002 isRetracted "false" @default.
• W2024176002 magId "2024176002" @default.
• W2024176002 workType "article" @default.