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• W2024177316 abstract "<i>Background/Aims:</i> Genetic risk factors have not been clearly established for vascular dementias (VaD) related to stroke and cerebrovascular disease. <i>Methods:</i> Samples were genotyped for <i>APOE</i>, <i>MTHFR</i> and <i>ICAM</i>. Aβ levels and choline acetyltransferase (ChAT) activities were assayed in controls and individuals with VaD. <i>Results:</i> Associations were found between the <i>APOE-</i>&#917;<i>4</i> allele and mixed dementia, infarct/stroke dementia and subcortical ischemic vascular dementia (SIVD), and higher Aβ1-42 levels and decreased ChAT activity. <i>MTHFR</i> was more associated with SIVD, mixed dementia, and lower ChAT activity. <i>Conclusions:</i> The study demonstrates important differences in the genetic associations of VaD and begins to clarify the genetic basis of key pathological substrates." @default.
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• W2024177316 date "2011-01-01" @default.
• W2024177316 modified "2023-10-18" @default.
• W2024177316 title "Genetic Associations of Autopsy-Confirmed Vascular Dementia Subtypes" @default.
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• W2024177316 doi "https://doi.org/10.1159/000327171" @default.
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