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• W2024177594 abstract "T‐cell receptor (TCR) &alpha; &beta; + CD4 − CD8 − (double‐negative; DN) T cells appear in the peritoneal cavity at an early stage of intraperitoneal (i.p.) infection with the intracellular pathogen Listeria monocytogenes . In the present report, we analysed the developmental pathway and functions of the TCR &alpha; &beta; + DN T cells using the L. monocytogenes infection system. The TCR &alpha; &beta; + DN T cells appeared in the peritoneal cavity after L. monocytogenes i.p. infection in adult‐thymectomized lethally irradiated bone marrow chimeras and p56 lck ‐deficient mice. The results demonstrated that the TCR &alpha; &beta; + DN T cells can develop extrathymically in a p56 lck ‐independent manner. Reverse transcription–polymerase chain reaction (RT‐PCR) analysis showed that the TCR &alpha; &beta; + DN T cells expressed genes for interferon‐ &gamma; (IFN‐ &gamma; ), the macrophage chemotactic factors MCP‐1 and Eta‐1, and granulocyte–macrophage colony‐stimulating factor (GM‐CSF) but lacked expression of genes for interleukin‐2 (IL‐2), IL‐4 and IL‐10. As expected from the RT‐PCR analysis, the TCR &alpha; &beta; + DN T cells produced IFN‐ &gamma; in response to anti‐TCR &beta; monoclonal antibody (mAb), anti‐CD3 mAb and L. monocytogenes ‐infected macrophages but IL‐4 was undetectable after the stimulation . Furthermore, the intracellular cytokine staining analysis demonstrated that approximately half of the TCR &alpha; &beta; + DN T cells detectable at the early stage of L. monocytogenes infection were IFN‐ &gamma; ‐producing cells. All of the results suggest that the TCR &alpha; &beta; + DN T cells develop through a unique extrathymic p56 lck ‐independent pathway and participate in early protection against bacterial infection through activation and accumulation of macrophages." @default.
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• W2024177594 date "1997-08-01" @default.
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• W2024177594 title "TCR <i>&alpha;</i> <i>&beta;</i> ⁺ CD4 ⁻ CD8 ⁻ T cells differentiate extrathymically in an <i>lck</i> ‐independent manner and participate in early response against <i>Listeria monocytogenes</i> infection through interferon‐ <i>&gamma;</i> production" @default.
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• W2024177594 doi "https://doi.org/10.1046/j.1365-2567.1997.00303.x" @default.
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