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- W2024180044 abstract "Abstract The effects of glucagon, insulin, and adrenalin on glucose production by Amphiuma means liver organ cultures maintained at 25° were studied. Glucagon stimulated gluconeogenesis from pyruvate and alanine, and adrenalin treatment resulted in a more rapid glycogenolysis than glucagon treatment. Glucagon increased the tissue levels of glutamate-oxaloacetate transaminase (GOT), glutamate-pyruvate transaminase (GPT), and fructose-1,6-diphosphatase after 40 hr, while insulin decreased GOT and GPT levels after 72 hr. The presence of pyruvate in the medium significantly reduced nitrogenous excretion by the liver fragments. We conclude that cultured A. means liver responds to glucagon, insulin, and adrenalin in ways that are compatible with the known effects of these hormones in mammals." @default.
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- W2024180044 date "1975-11-01" @default.
- W2024180044 modified "2023-10-18" @default.
- W2024180044 title "Hormonal control of glucose production by Amphiuma means liver in organ culture" @default.
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- W2024180044 doi "https://doi.org/10.1016/0016-6480(75)90205-1" @default.
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