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• W2024182110 endingPage "231" @default.
• W2024182110 startingPage "221" @default.
• W2024182110 abstract "Posttranslational modifications of proliferating cell nuclear antigen (PCNA), the eukaryotic processivity clamp for DNA polymerases, regulate the pathways by which replication problems are resolved. In the budding yeast Saccharomyces cerevisiae, ubiquitylation of PCNA in response to DNA damage facilitates the replicative bypass of lesions, whereas conjugation of the ubiquitin-related modifier (SUMO) prevents unscheduled crossover events during S phase. We have analyzed the SUMO modification pattern of budding yeast PCNA in vivo and in vitro and found that most aspects of our in vitro sumoylation reactions reflect the situation under physiological conditions. We show that two oligomeric SUMO chains of two to three moieties each, linked via internal sumoylation consensus motifs within the SUMO sequence, are assembled on PCNA. The SUMO-specific ligase Siz1 both stimulates the overall efficiency of sumoylation and selects the modification site on PCNA. Furthermore, ubiquitin and SUMO chains are assembled independently, and we found evidence that both modifiers can coexist in vivo on a common PCNA subunit. Our results demonstrate for the first time the in vivo assembly of polymeric SUMO chains of defined linkage on a physiological substrate in yeast, but they also indicate that SUMO-SUMO polymers are dispensable for PCNA(SUMO) function in replication and recombination." @default.
• W2024182110 created "2016-06-24" @default.
• W2024182110 creator A5064912774 @default.
• W2024182110 creator A5077688118 @default.
• W2024182110 date "2008-02-01" @default.
• W2024182110 modified "2023-10-16" @default.
• W2024182110 title "Architecture and Assembly of Poly-SUMO Chains on PCNA in Saccharomyces cerevisiae" @default.
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• W2024182110 doi "https://doi.org/10.1016/j.jmb.2007.12.008" @default.
• W2024182110 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18155241" @default.
• W2024182110 hasPublicationYear "2008" @default.
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