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- W2024182261 abstract "Non steroidal anti-inflammatory medications are known to cause constriction of the ductus arteriosus (DA). DA constriction after the use of acetaminophen in the third trimester of pregnancy has not been reported in the literature. Women commonly suffer from back pain in the second half of pregnancy and seek relief from over-the-counter (OTC) medications. We report two cases of DA constriction from OTC self-prescribed pain medication: 1. A 36 year old G3 P1011 had fetal echocardiography (FECHO) at 29 weeks for oligohydramnios. The patient was taking only daily acetaminophen 1000 mg per day for back pain. The fetus had distinct narrowing of the DA, with a pulsatility index (PI) of 2.03 (normal value = 2.40–3.80) and peak systolic velocity (PSV) of 240 cm/sec (normal value = 80–160 cm/sec) with biventricular hypertrophy. After 7 days off acetaminophen, there was no ductal constriction and normal DA PI values. 2. A 37 year old, G2 P0010 had FECHO at 33 weeks for pericardial effusion detected at a growth scan. The patient had taken 400 mg of ibuprofen once the previous night for back pain. The fetus had distinct narrowing of the DA, PI of 1.35 and PSV of 260 cm/sec with tricuspid valve regurgitation and a prolonged atrio-ventricular time interval. She was delivered 1 day later for prolonged decelerations on fetal strip monitoring. We conclude that pregnant women should be advised to limit the use of OTC pain medications in the third trimester." @default.
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- W2024182261 date "2008-08-01" @default.
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- W2024182261 title "P26.12: Self-medicated acetaminophen and ibuprofen in the third trimester of pregnancy can cause constriction of the fetal ductus arteriosus (DA): A report of 2 cases" @default.
- W2024182261 doi "https://doi.org/10.1002/uog.5928" @default.
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