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- W2024183147 abstract "The ability of l-α-acetylmethadol (LAAM) to induce ocular opacities was studied in rats. Between the third and fifth days after subcutaneous or oral administration of a single dose of LAAM, a dose-dependent incidence of opacification of the anterior segments of rat eyes was observed. Observation of the eyes of LAAM-treated rats, using a dissection microscope and a slit beam biomicroscope, indicated that the opacities were localized to the cornea and the depth of corneal involvement varied from patches of grayish epithelium to full-thickness involvement. Light microscopy of eye sections from rats given LAAM, 20 mg/kg orally, revealed corneal changes ranging from thickening and loss of regularity of epithelial cell layers to stromal vascularization and spindle cell infiltration. The sc and oral ED-50 for LAAM-induced corneal opacities was found to be 4.7 (4.2–5.3) and 12.6 (9.8–16.1) mg/kg, respectively. This is similar to or lower than the ED-50 for pharmacological effects of LAAM such as analgesia and mydriasis. The mechanism(s) by which LAAM initiates the corneal opacities is unknown. However, in rats made tolerant to morphine by implantation of a morphine pellet, we observed a threefold tolerance to LAAM-induced corneal opacities, suggesting a central nervous system mechanism in the development of the observed corneal changes." @default.
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- W2024183147 title "Occurrence of corneal opacities in rats after acute administration of l-?-acetylmethadol" @default.
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- W2024183147 doi "https://doi.org/10.1016/0041-008x(80)90285-9" @default.
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