FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024187657> ?p ?o ?g. }

• W2024187657 endingPage "520" @default.
• W2024187657 startingPage "514" @default.
• W2024187657 abstract "Vibrio anguillarum is the etiological agent of vibriosis, an aquaculture disease that affects a wide range of farmed fish. The genome of V. anguillarum contains five flagellin genes, i.e. flaA, flaB, flaC, flaD, and flaE. In this study, we analyzed the vaccine potential and adjuvanticity of FlaA, FlaB, FlaD, and FlaE in a model of Japanese flounder (Paralichthys olivaceus). For this purpose, recombinant FlaA, FlaB, FlaD, and FlaE were expressed in and purified from Escherichia coli. In vivo immunogenicity analysis showed that antibodies against rFlaA, rFlaB, rFlaD, and rFlaE were detected in rat antiserum raised against live V. anguillarum, with the highest antibody level being that against rFlaB. When administered into flounder via intraperitoneal injection, rFlaA, rFlaD, and rFlaE induced comparable relative percent survival (RPS) rates, which were significantly lower than that induced by rFlaB. Specific serum antibodies were induced by all flagellins, however, the antibody level induced by rFlaB was significantly higher than those induced by other three flagellins. Compared to sera from fish vaccinated with rFlaA, rFlaD, and rFlaE, serum from fish vaccinated with rFlaB significantly reduced the infectivity of V. anguillarum against host cells. To examine the potential adjuvant effect of the flagellins, flounder were immunized with rEsa1, a D15-like surface antigen that induces protective immunity as a subunit vaccine, in the presence or absence of rFlaA, rFlaB, rFlaD, and rFlaE respectively. The results showed that rFlaE, but not other three flagellins, significantly increased the RPS of rEsa1. Compared to fish vaccinated with rEsa1, fish vaccinated with rEsa1 plus rFlaE exhibited a significantly higher level of serum antibodies and enhanced expression of the genes involved in innate and adaptive immunity. Taken together, these results indicate that FlaA, FlaB, FlaD, and FlaE have different immunological properties and, as a result, differ in vaccine and adjuvant potentials." @default.
• W2024187657 created "2016-06-24" @default.
• W2024187657 creator A5003147636 @default.
• W2024187657 creator A5003946481 @default.
• W2024187657 creator A5010995240 @default.
• W2024187657 creator A5012225184 @default.
• W2024187657 creator A5049415248 @default.
• W2024187657 creator A5069770938 @default.
• W2024187657 date "2013-02-01" @default.
• W2024187657 modified "2023-09-26" @default.
• W2024187657 title "Comparative study of four flagellins of Vibrio anguillarum: Vaccine potential and adjuvanticity" @default.
• W2024187657 cites W1507063812 @default.
• W2024187657 cites W1519633296 @default.
• W2024187657 cites W1671931635 @default.
• W2024187657 cites W1776637609 @default.
• W2024187657 cites W1978897589 @default.
• W2024187657 cites W1985973479 @default.
• W2024187657 cites W1989860945 @default.
• W2024187657 cites W1990177413 @default.
• W2024187657 cites W1995587232 @default.
• W2024187657 cites W1998641031 @default.
• W2024187657 cites W2005513649 @default.
• W2024187657 cites W2012320318 @default.
• W2024187657 cites W2020040553 @default.
• W2024187657 cites W2024182868 @default.
• W2024187657 cites W2024238985 @default.
• W2024187657 cites W2034265657 @default.
• W2024187657 cites W2038276497 @default.
• W2024187657 cites W2045628772 @default.
• W2024187657 cites W2048931146 @default.
• W2024187657 cites W2052003687 @default.
• W2024187657 cites W2055773854 @default.
• W2024187657 cites W2058003226 @default.
• W2024187657 cites W2060166908 @default.
• W2024187657 cites W2064747653 @default.
• W2024187657 cites W2075948284 @default.
• W2024187657 cites W2081578705 @default.
• W2024187657 cites W2098779043 @default.
• W2024187657 cites W2099399224 @default.
• W2024187657 cites W2105712092 @default.
• W2024187657 cites W2106510584 @default.
• W2024187657 cites W2118996088 @default.
• W2024187657 cites W2123879032 @default.
• W2024187657 cites W2126953691 @default.
• W2024187657 cites W2130501069 @default.
• W2024187657 cites W2135710441 @default.
• W2024187657 cites W2137003603 @default.
• W2024187657 cites W2149000191 @default.
• W2024187657 cites W2149931989 @default.
• W2024187657 cites W2152278126 @default.
• W2024187657 cites W2157129863 @default.
• W2024187657 cites W2159923852 @default.
• W2024187657 cites W2166236008 @default.
• W2024187657 cites W2168063573 @default.
• W2024187657 cites W4249383371 @default.
• W2024187657 doi "https://doi.org/10.1016/j.fsi.2012.11.039" @default.
• W2024187657 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23253494" @default.
• W2024187657 hasPublicationYear "2013" @default.
• W2024187657 type Work @default.
• W2024187657 sameAs 2024187657 @default.
• W2024187657 citedByCount "17" @default.
• W2024187657 countsByYear W20241876572015 @default.
• W2024187657 countsByYear W20241876572016 @default.
• W2024187657 countsByYear W20241876572017 @default.
• W2024187657 countsByYear W20241876572018 @default.
• W2024187657 countsByYear W20241876572019 @default.
• W2024187657 countsByYear W20241876572021 @default.
• W2024187657 countsByYear W20241876572022 @default.
• W2024187657 crossrefType "journal-article" @default.
• W2024187657 hasAuthorship W2024187657A5003147636 @default.
• W2024187657 hasAuthorship W2024187657A5003946481 @default.
• W2024187657 hasAuthorship W2024187657A5010995240 @default.
• W2024187657 hasAuthorship W2024187657A5012225184 @default.
• W2024187657 hasAuthorship W2024187657A5049415248 @default.
• W2024187657 hasAuthorship W2024187657A5069770938 @default.
• W2024187657 hasConcept C147483822 @default.
• W2024187657 hasConcept C159047783 @default.
• W2024187657 hasConcept C159654299 @default.
• W2024187657 hasConcept C203014093 @default.
• W2024187657 hasConcept C2776154503 @default.
• W2024187657 hasConcept C2776367567 @default.
• W2024187657 hasConcept C2776533291 @default.
• W2024187657 hasConcept C2777863537 @default.
• W2024187657 hasConcept C2779026604 @default.
• W2024187657 hasConcept C2780868878 @default.
• W2024187657 hasConcept C2781348184 @default.
• W2024187657 hasConcept C2909208804 @default.
• W2024187657 hasConcept C2911179620 @default.
• W2024187657 hasConcept C38117629 @default.
• W2024187657 hasConcept C505870484 @default.
• W2024187657 hasConcept C523546767 @default.
• W2024187657 hasConcept C54355233 @default.
• W2024187657 hasConcept C86803240 @default.
• W2024187657 hasConcept C8891405 @default.
• W2024187657 hasConcept C89423630 @default.
• W2024187657 hasConceptScore W2024187657C147483822 @default.
• W2024187657 hasConceptScore W2024187657C159047783 @default.
• W2024187657 hasConceptScore W2024187657C159654299 @default.

• next