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- W2024188077 abstract "This study compared the impact of two perfusates (A: 4.5% BSA-MOPS buffer and B: 4% dextran and 0.5% BSA-MOPS buffer) on the pharmacokinetics of the physiological markers [3H]-water, [14C]-sucrose, [14C]-antipyrine and Evans Blue-labelled albumin; and the drugs atenolol and propranolol using an in-situ single pass perfusion model in the rat lung. The multiple indicator dilution approach was used to define disposition. Similar perfusion pressures (17.6 ± 6.71 vs 17.7 ± 8.87 cmH2O), lung wet/dry ratio (6.14 ± 1.16 vs 5.16 ± 0.87), physiological spaces, and permeability-surface area products were found for the two perfusates. However, the recovery of propranolol using perfusate A (49.3 ± 10.1%) was significantly higher than that using perfusate B (38.9 ± 9.91%). This difference was consistent with changes in perfusate oncotic pressure associated with water and albumin distribution between the vascular, interstitial and cellular volumes of the lung." @default.
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- W2024188077 date "2009-12-01" @default.
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- W2024188077 title "Influence of perfusate composition on drug disposition in the in-situ perfused rat lung" @default.
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- W2024188077 doi "https://doi.org/10.1016/j.ijpharm.2009.08.028" @default.
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