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- W2024188432 abstract "EtOAc extracts from two batches of Morus alba root bark (Sang bai pi) potentiated γ-aminobutyric acid (GABA)-induced chloride influx in Xenopus oocytes, which transiently expressed GABAA receptors of the subunit composition α 1 β 2 γ 2S. With the aid of HPLC-based activity profiling of the extract from the first batch, activity was traced to a peak subsequently identified as sanggenon G (3). The second batch had a different phytochemical profile, and HPLC-based activity profiling led to the identification of sanggenon C (4) and a stereoisomer of sanggenon D (2) as positive GABAA receptor modulators. The structurally related compound kuwanon L (1) was inactive. The sanggenons represent a new scaffold of positive GABAA receptor modulators." @default.
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- W2024188432 date "2012-01-31" @default.
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- W2024188432 title "HPLC-based Activity Profiling - Discovery of Sanggenons as GABA<sub>A</sub>Receptor Modulators in the Traditional Chinese Drug Sang bai pi (<i>Morus alba</i>Root Bark)" @default.
- W2024188432 doi "https://doi.org/10.1055/s-0031-1298229" @default.
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