Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024190010> ?p ?o ?g. }
- W2024190010 endingPage "153" @default.
- W2024190010 startingPage "147" @default.
- W2024190010 abstract "Maternal smoking in utero has been associated with adverse health outcomes including lower respiratory tract infections in infants and children, but the mechanisms underlying these associations continue to be investigated. We hypothesized that nicotine plays a significant role in mediating the effects of maternal tobacco smoke on the function of the neonatal alveolar macrophage (AM), the resident immune cell in the neonatal lung. Primary AMs were isolated at postnatal day 7 from a murine model of in utero nicotine exposure. The murine AM cell line MH-S was used for additional in vitro studies. In utero nicotine increased interleukin-13 and transforming growth factor–β1 (TGFβ1) in the neonatal lung. Nicotine-exposed AMs demonstrated increased TGFβ1 and increased markers of alternative activation with diminished phagocytic function. However, AMs from mice deficient in the α7 nicotinic acetylcholine receptor (α7 nAChR) had less TGFβ1, reduced alternative activation, and improved phagocytic functioning despite similar in utero nicotine exposure. In utero nicotine exposure, mediated in part via the α7 nAChR, may increase the risk of lower respiratory tract infections in neonates by changing the resting state of AM toward alternative activation. These findings have important implications for immune responses in the nicotine-exposed neonatal lung." @default.
- W2024190010 created "2016-06-24" @default.
- W2024190010 creator A5001823079 @default.
- W2024190010 creator A5013087896 @default.
- W2024190010 creator A5018252869 @default.
- W2024190010 creator A5023165771 @default.
- W2024190010 creator A5029783707 @default.
- W2024190010 creator A5047040884 @default.
- W2024190010 creator A5063708958 @default.
- W2024190010 creator A5070324498 @default.
- W2024190010 creator A5073349266 @default.
- W2024190010 date "2012-05-04" @default.
- W2024190010 modified "2023-10-12" @default.
- W2024190010 title "In utero nicotine exposure promotes M2 activation in neonatal mouse alveolar macrophages" @default.
- W2024190010 cites W123264792 @default.
- W2024190010 cites W1550642465 @default.
- W2024190010 cites W1840439659 @default.
- W2024190010 cites W1882263729 @default.
- W2024190010 cites W1955724354 @default.
- W2024190010 cites W1969942782 @default.
- W2024190010 cites W1971876086 @default.
- W2024190010 cites W1974552803 @default.
- W2024190010 cites W1978392269 @default.
- W2024190010 cites W1980817113 @default.
- W2024190010 cites W1986798641 @default.
- W2024190010 cites W1988379233 @default.
- W2024190010 cites W1993612982 @default.
- W2024190010 cites W2004396981 @default.
- W2024190010 cites W2004979724 @default.
- W2024190010 cites W2008728858 @default.
- W2024190010 cites W2043523970 @default.
- W2024190010 cites W2066072238 @default.
- W2024190010 cites W2072872532 @default.
- W2024190010 cites W2079696750 @default.
- W2024190010 cites W2081659051 @default.
- W2024190010 cites W2089571230 @default.
- W2024190010 cites W2095537212 @default.
- W2024190010 cites W2117997757 @default.
- W2024190010 cites W2122212067 @default.
- W2024190010 cites W2128627731 @default.
- W2024190010 cites W2137923057 @default.
- W2024190010 cites W2143076349 @default.
- W2024190010 cites W2146710322 @default.
- W2024190010 cites W2163601934 @default.
- W2024190010 cites W2164578308 @default.
- W2024190010 cites W2170822548 @default.
- W2024190010 cites W2276614885 @default.
- W2024190010 cites W4293247451 @default.
- W2024190010 doi "https://doi.org/10.1038/pr.2012.55" @default.
- W2024190010 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3600420" @default.
- W2024190010 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22562289" @default.
- W2024190010 hasPublicationYear "2012" @default.
- W2024190010 type Work @default.
- W2024190010 sameAs 2024190010 @default.
- W2024190010 citedByCount "27" @default.
- W2024190010 countsByYear W20241900102012 @default.
- W2024190010 countsByYear W20241900102013 @default.
- W2024190010 countsByYear W20241900102014 @default.
- W2024190010 countsByYear W20241900102015 @default.
- W2024190010 countsByYear W20241900102016 @default.
- W2024190010 countsByYear W20241900102017 @default.
- W2024190010 countsByYear W20241900102018 @default.
- W2024190010 countsByYear W20241900102019 @default.
- W2024190010 countsByYear W20241900102020 @default.
- W2024190010 countsByYear W20241900102021 @default.
- W2024190010 countsByYear W20241900102022 @default.
- W2024190010 crossrefType "journal-article" @default.
- W2024190010 hasAuthorship W2024190010A5001823079 @default.
- W2024190010 hasAuthorship W2024190010A5013087896 @default.
- W2024190010 hasAuthorship W2024190010A5018252869 @default.
- W2024190010 hasAuthorship W2024190010A5023165771 @default.
- W2024190010 hasAuthorship W2024190010A5029783707 @default.
- W2024190010 hasAuthorship W2024190010A5047040884 @default.
- W2024190010 hasAuthorship W2024190010A5063708958 @default.
- W2024190010 hasAuthorship W2024190010A5070324498 @default.
- W2024190010 hasAuthorship W2024190010A5073349266 @default.
- W2024190010 hasBestOaLocation W20241900101 @default.
- W2024190010 hasConcept C126322002 @default.
- W2024190010 hasConcept C134018914 @default.
- W2024190010 hasConcept C172680121 @default.
- W2024190010 hasConcept C201614185 @default.
- W2024190010 hasConcept C203014093 @default.
- W2024190010 hasConcept C2779234561 @default.
- W2024190010 hasConcept C2779547902 @default.
- W2024190010 hasConcept C2779644171 @default.
- W2024190010 hasConcept C534529494 @default.
- W2024190010 hasConcept C54355233 @default.
- W2024190010 hasConcept C71924100 @default.
- W2024190010 hasConcept C86803240 @default.
- W2024190010 hasConceptScore W2024190010C126322002 @default.
- W2024190010 hasConceptScore W2024190010C134018914 @default.
- W2024190010 hasConceptScore W2024190010C172680121 @default.
- W2024190010 hasConceptScore W2024190010C201614185 @default.
- W2024190010 hasConceptScore W2024190010C203014093 @default.
- W2024190010 hasConceptScore W2024190010C2779234561 @default.
- W2024190010 hasConceptScore W2024190010C2779547902 @default.
- W2024190010 hasConceptScore W2024190010C2779644171 @default.
- W2024190010 hasConceptScore W2024190010C534529494 @default.