FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024191204> ?p ?o ?g. }

• W2024191204 endingPage "F19" @default.
• W2024191204 startingPage "F9" @default.
• W2024191204 abstract "New and effective treatment for acute kidney injury remains a challenge. Here, we induced mouse hematopoietic stem and progenitor cells (HSPC) to differentiate into cells that partially resemble a renal cell phenotype and tested their therapeutic potential. We sequentially treated HSPC with a combination of protein factors for 1 wk to generate a large number of cells that expressed renal developmentally regulated genes and protein. Cell fate conversion was associated with increased histone acetylation on promoters of renal-related genes. Further treatment of the cells with a histone deacetylase inhibitor improved the efficiency of cell conversion by sixfold. Treated cells formed tubular structures in three-dimensional cultures and were integrated into tubules of embryonic kidney organ cultures. When injected under the renal capsule, they integrated into renal tubules of postischemic kidneys and expressed the epithelial marker E-cadherin. No teratoma formation was detected 2 and 6 mo after cell injection, supporting the safety of using these cells. Furthermore, intravenous injection of the cells into mice with renal ischemic injury improved kidney function and morphology by increasing endogenous renal repair and decreasing tubular cell death. The cells produced biologically effective concentrations of renotrophic factors including VEGF, IGF-1, and HGF to stimulate epithelial proliferation and tubular repair. Our study indicates that hematopoietic stem and progenitor cells can be converted to a large number of renal-like cells within a short period for potential treatment of acute kidney injury." @default.
• W2024191204 created "2016-06-24" @default.
• W2024191204 creator A5003165517 @default.
• W2024191204 creator A5010351891 @default.
• W2024191204 creator A5017281066 @default.
• W2024191204 creator A5056329233 @default.
• W2024191204 creator A5083411426 @default.
• W2024191204 creator A5089730392 @default.
• W2024191204 date "2012-01-01" @default.
• W2024191204 modified "2023-10-06" @default.
• W2024191204 title "Use of mouse hematopoietic stem and progenitor cells to treat acute kidney injury" @default.
• W2024191204 cites W185287585 @default.
• W2024191204 cites W1966420336 @default.
• W2024191204 cites W1967049808 @default.
• W2024191204 cites W1970515177 @default.
• W2024191204 cites W1978261848 @default.
• W2024191204 cites W1979981202 @default.
• W2024191204 cites W1980020302 @default.
• W2024191204 cites W1982838274 @default.
• W2024191204 cites W1989315132 @default.
• W2024191204 cites W1994634932 @default.
• W2024191204 cites W2018091219 @default.
• W2024191204 cites W2024425375 @default.
• W2024191204 cites W2039551265 @default.
• W2024191204 cites W2042982622 @default.
• W2024191204 cites W2043155095 @default.
• W2024191204 cites W2047015004 @default.
• W2024191204 cites W2073988961 @default.
• W2024191204 cites W2078364998 @default.
• W2024191204 cites W2082355794 @default.
• W2024191204 cites W2083125769 @default.
• W2024191204 cites W2083356835 @default.
• W2024191204 cites W2087137170 @default.
• W2024191204 cites W2095643982 @default.
• W2024191204 cites W2097577343 @default.
• W2024191204 cites W2097774432 @default.
• W2024191204 cites W2100648382 @default.
• W2024191204 cites W2109627278 @default.
• W2024191204 cites W2114166108 @default.
• W2024191204 cites W2114522784 @default.
• W2024191204 cites W2119774673 @default.
• W2024191204 cites W2122677163 @default.
• W2024191204 cites W2124426981 @default.
• W2024191204 cites W2125987139 @default.
• W2024191204 cites W2132860647 @default.
• W2024191204 cites W2136541538 @default.
• W2024191204 cites W2138561620 @default.
• W2024191204 cites W2138977668 @default.
• W2024191204 cites W2140979322 @default.
• W2024191204 cites W2142046859 @default.
• W2024191204 cites W2144582052 @default.
• W2024191204 cites W2144676126 @default.
• W2024191204 cites W2145901145 @default.
• W2024191204 cites W2149199764 @default.
• W2024191204 cites W2149386327 @default.
• W2024191204 cites W2158814382 @default.
• W2024191204 cites W2162923280 @default.
• W2024191204 cites W2165135585 @default.
• W2024191204 cites W2166234655 @default.
• W2024191204 cites W2167202160 @default.
• W2024191204 cites W2181008715 @default.
• W2024191204 cites W2182633717 @default.
• W2024191204 doi "https://doi.org/10.1152/ajprenal.00377.2011" @default.
• W2024191204 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3251347" @default.
• W2024191204 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21937606" @default.
• W2024191204 hasPublicationYear "2012" @default.
• W2024191204 type Work @default.
• W2024191204 sameAs 2024191204 @default.
• W2024191204 citedByCount "27" @default.
• W2024191204 countsByYear W20241912042012 @default.
• W2024191204 countsByYear W20241912042013 @default.
• W2024191204 countsByYear W20241912042014 @default.
• W2024191204 countsByYear W20241912042015 @default.
• W2024191204 countsByYear W20241912042016 @default.
• W2024191204 countsByYear W20241912042017 @default.
• W2024191204 countsByYear W20241912042018 @default.
• W2024191204 countsByYear W20241912042019 @default.
• W2024191204 countsByYear W20241912042021 @default.
• W2024191204 countsByYear W20241912042023 @default.
• W2024191204 crossrefType "journal-article" @default.
• W2024191204 hasAuthorship W2024191204A5003165517 @default.
• W2024191204 hasAuthorship W2024191204A5010351891 @default.
• W2024191204 hasAuthorship W2024191204A5017281066 @default.
• W2024191204 hasAuthorship W2024191204A5056329233 @default.
• W2024191204 hasAuthorship W2024191204A5083411426 @default.
• W2024191204 hasAuthorship W2024191204A5089730392 @default.
• W2024191204 hasBestOaLocation W20241912042 @default.
• W2024191204 hasConcept C104317684 @default.
• W2024191204 hasConcept C109159458 @default.
• W2024191204 hasConcept C126322002 @default.
• W2024191204 hasConcept C134018914 @default.
• W2024191204 hasConcept C138798377 @default.
• W2024191204 hasConcept C145103041 @default.
• W2024191204 hasConcept C201750760 @default.
• W2024191204 hasConcept C2780091579 @default.
• W2024191204 hasConcept C2780472472 @default.
• W2024191204 hasConcept C28328180 @default.
• W2024191204 hasConcept C502942594 @default.

• next