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- W2024191964 abstract "Cyanidin-3-rutinoside (C3R), a naturally occurring anthocyanin, is present in various fruits and vegetables as a colorant. C3R has been well characterized and demonstrated a number of biological activities attributed to its antioxidant properties. The present study compared the effectiveness of C3R against monosaccharide-induced protein glycation and oxidation in vitro using bovine serum albumin (BSA).The results demonstrated that C3R (0.125–1.00 mM) inhibited the formation of fluorescent AGEs in ribose-glycated BSA (2–52%), fructose-glycated BSA (81–93%), glucose-glycated BSA (30–74%) and galactose-glycated BSA (6-79%).Correspondingly, C3R (1.00 mM) decreased the level of Nɛ-(carboxymethyl) lysine (56-86%) in monosaccharide-induced glycation in BSA. C3R also reduced the level of fructosamine, β-amyloid cross structure, protein carbonyl content as well as the depletion of thiol in BSA/monosaccharide system. In summary, C3R might offer a new promising antiglycation agent for the prevention of diabetic complications by inhibiting AGE formation and oxidation-dependent protein damage." @default.
- W2024191964 created "2016-06-24" @default.
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- W2024191964 date "2015-04-01" @default.
- W2024191964 modified "2023-10-15" @default.
- W2024191964 title "Protective effects of cyanidin-3-rutinoside against monosaccharides-induced protein glycation and oxidation" @default.
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- W2024191964 doi "https://doi.org/10.1016/j.ijbiomac.2015.02.004" @default.
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