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- W2024192700 abstract "In Reply.— We agree that our data do not prove DTP immunization never causes encephalopathy; our study of 38 171 children with 107154 immunizations did not have sufficient power to detect rare events. However, the consistency of our findings with those of two other recent controlled studies of this question1,2led us to comment that if there are encephalopathies caused by DTP immunization, they must be rare. We disagree with the presumption of Tilelli and Manniello that it is established that DTP immunization can cause encephalopathies. Uncontrolled case reports and observations by individual pediatricians do not constitute a scientific basis for establishing causality. The information cited from the 1986 Redbook3is based on the British National Childhood Encephalopathy Study; recent reanalysis of these data4have cast doubt on the original finding of an association between DTP immunization and permanent neurological damage. Thus, the extant data are" @default.
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- W2024192700 date "1990-11-14" @default.
- W2024192700 modified "2023-09-25" @default.
- W2024192700 title "Pertussis Vaccine Encephalopathy-Reply" @default.
- W2024192700 cites W1537316685 @default.
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- W2024192700 doi "https://doi.org/10.1001/jama.1990.03450180039020" @default.
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