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- W2024192983 endingPage "117" @default.
- W2024192983 startingPage "110" @default.
- W2024192983 abstract "Fragile X Syndrome (FXS) is a trinucleotide repeat disorder that results in the silencing of the Fragile X Mental Retardation 1 gene (FMR1), leading to a lack of the FMR1 protein (FMRP). FMRP is an mRNA-binding protein that regulates the translation of hundreds of mRNAs important for synaptic plasticity. Several of these pathways have been identified and have guided the development of targeted treatments for FXS. Here we present evidence that serotonin is dysregulated in FXS and treatment with the selective serotonin reuptake inhibitor (SSRI) sertraline may be beneficial for individuals with FXS, particularly in early childhood." @default.
- W2024192983 created "2016-06-24" @default.
- W2024192983 creator A5015285662 @default.
- W2024192983 creator A5086196058 @default.
- W2024192983 date "2014-01-01" @default.
- W2024192983 modified "2023-10-06" @default.
- W2024192983 title "Serotonin dysregulation in Fragile X Syndrome: implications for treatment" @default.
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- W2024192983 doi "https://doi.org/10.5582/irdr.2014.01027" @default.
- W2024192983 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4298641" @default.
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