FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024193228> ?p ?o ?g. }

• W2024193228 endingPage "278" @default.
• W2024193228 startingPage "268" @default.
• W2024193228 abstract "Helicobacter pylori (H. pylori) infection is associated with chronic infiltration into the stomach by T cells and plasma cells producing IFN-gamma and antibodies of various specificities, respectively. It is unknown whether these lymphocyte-products may play coordinated roles in the gastric pathology of this infection.To know how IFN-gamma may relate to anti-H. pylori antibodies in their roles in pathogenesis, we determined the isotype subclass of those antibodies as well as their cross-reactivity and cytotoxicity to gastric epithelium.We infected BALB/c mice with H. pylori (SS1, Sydney Strain 1) and generated monoclonal antibodies, which were comprised of 240 independent clones secreting immunoglobulin and included 80 clones reactive to SS1. Ninety percent of the SS1-reactive clones had IgG2a isotype. Two clones, 2B10 and 1A9, were cross reactive to cell surface antigens in H. pylori and to antigens of 28 KDa and 42 KDa, respectively, which were present on the cell surface of and shared by both mouse and human gastric epithelial cells. The antigens recognized by these monoclonal antibodies localized a distinctive area in the gastric glands. In the presence of complement, 2B10 showed cytotoxicity to gastric epithelial cells. The effect was dose dependant and augmented by IFN-gamma. Finally, administration of 2B10 to mice with SS1 infection aggravated gastritis by increasing cellular infiltration.IFN-gamma by gastric T cells may participate in pathogenesis of the H. pylori infected stomach by directing an isotype-switch of anti-H. pylori antibodies to complement-binding subclass and by augmenting cytotoxic activity of a certain autoantibody. This may explain a host-dependent diversity in gastric pathology of the patients with H. pylori infection." @default.
• W2024193228 created "2016-06-24" @default.
• W2024193228 creator A5004029965 @default.
• W2024193228 creator A5009867090 @default.
• W2024193228 creator A5029436502 @default.
• W2024193228 creator A5060893642 @default.
• W2024193228 creator A5084715689 @default.
• W2024193228 date "2003-08-01" @default.
• W2024193228 modified "2023-10-15" @default.
• W2024193228 title "A Coordinated Cytotoxic Effect of IFN-gamma and Cross-Reactive Antibodies in the Pathogenesis of Helicobacter pylori Gastritis" @default.
• W2024193228 cites W1514708659 @default.
• W2024193228 cites W1561530553 @default.
• W2024193228 cites W1656119173 @default.
• W2024193228 cites W1666864975 @default.
• W2024193228 cites W1948053391 @default.
• W2024193228 cites W1961145259 @default.
• W2024193228 cites W1968465063 @default.
• W2024193228 cites W1973232347 @default.
• W2024193228 cites W1973860286 @default.
• W2024193228 cites W1973985938 @default.
• W2024193228 cites W1975436067 @default.
• W2024193228 cites W1977011623 @default.
• W2024193228 cites W1982189025 @default.
• W2024193228 cites W1990705971 @default.
• W2024193228 cites W1998707179 @default.
• W2024193228 cites W2001833334 @default.
• W2024193228 cites W2006354480 @default.
• W2024193228 cites W2007055114 @default.
• W2024193228 cites W2018112828 @default.
• W2024193228 cites W2021050685 @default.
• W2024193228 cites W2022041292 @default.
• W2024193228 cites W2026152073 @default.
• W2024193228 cites W2028247108 @default.
• W2024193228 cites W2029077196 @default.
• W2024193228 cites W2029851838 @default.
• W2024193228 cites W2037681980 @default.
• W2024193228 cites W2044727420 @default.
• W2024193228 cites W2047053776 @default.
• W2024193228 cites W2051614380 @default.
• W2024193228 cites W2059487210 @default.
• W2024193228 cites W2059614271 @default.
• W2024193228 cites W2063121433 @default.
• W2024193228 cites W2064748217 @default.
• W2024193228 cites W2065670972 @default.
• W2024193228 cites W2066739766 @default.
• W2024193228 cites W2068076612 @default.
• W2024193228 cites W2069378448 @default.
• W2024193228 cites W2085770333 @default.
• W2024193228 cites W2097893222 @default.
• W2024193228 cites W2097941690 @default.
• W2024193228 cites W2099566069 @default.
• W2024193228 cites W2099982795 @default.
• W2024193228 cites W2107403957 @default.
• W2024193228 cites W2109770898 @default.
• W2024193228 cites W2114988680 @default.
• W2024193228 cites W2131796994 @default.
• W2024193228 cites W2139666009 @default.
• W2024193228 cites W2170788991 @default.
• W2024193228 cites W2170857500 @default.
• W2024193228 cites W4231330158 @default.
• W2024193228 cites W4249175969 @default.
• W2024193228 cites W4313342448 @default.
• W2024193228 doi "https://doi.org/10.1046/j.1523-5378.2003.00154.x" @default.
• W2024193228 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12950599" @default.
• W2024193228 hasPublicationYear "2003" @default.
• W2024193228 type Work @default.
• W2024193228 sameAs 2024193228 @default.
• W2024193228 citedByCount "8" @default.
• W2024193228 countsByYear W20241932282014 @default.
• W2024193228 countsByYear W20241932282015 @default.
• W2024193228 countsByYear W20241932282016 @default.
• W2024193228 countsByYear W20241932282019 @default.
• W2024193228 crossrefType "journal-article" @default.
• W2024193228 hasAuthorship W2024193228A5004029965 @default.
• W2024193228 hasAuthorship W2024193228A5009867090 @default.
• W2024193228 hasAuthorship W2024193228A5029436502 @default.
• W2024193228 hasAuthorship W2024193228A5060893642 @default.
• W2024193228 hasAuthorship W2024193228A5084715689 @default.
• W2024193228 hasConcept C147483822 @default.
• W2024193228 hasConcept C154317977 @default.
• W2024193228 hasConcept C159654299 @default.
• W2024193228 hasConcept C202751555 @default.
• W2024193228 hasConcept C203014093 @default.
• W2024193228 hasConcept C2776409635 @default.
• W2024193228 hasConcept C2777991845 @default.
• W2024193228 hasConcept C2780942790 @default.
• W2024193228 hasConcept C542903549 @default.
• W2024193228 hasConcept C54355233 @default.
• W2024193228 hasConcept C55493867 @default.
• W2024193228 hasConcept C86803240 @default.
• W2024193228 hasConceptScore W2024193228C147483822 @default.
• W2024193228 hasConceptScore W2024193228C154317977 @default.
• W2024193228 hasConceptScore W2024193228C159654299 @default.
• W2024193228 hasConceptScore W2024193228C202751555 @default.
• W2024193228 hasConceptScore W2024193228C203014093 @default.
• W2024193228 hasConceptScore W2024193228C2776409635 @default.
• W2024193228 hasConceptScore W2024193228C2777991845 @default.
• W2024193228 hasConceptScore W2024193228C2780942790 @default.

• next