FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024193334> ?p ?o ?g. }

• W2024193334 endingPage "344" @default.
• W2024193334 startingPage "339" @default.
• W2024193334 abstract "Intracellular hydration may play a role in the regulation of protein and nitrogen metabolism. The hepatic removal of nitrogen by urea synthesis has a key regulatory role in nitrogen balance. The purpose of the present study was to establish the acute effects of dehydration on the hepatic kinetics of urea synthesis, quantified by functional hepatic nitrogen clearance (FHNC), in healthy volunteers. Seven healthy men were studied twice in random order. On both study days, a primed continuous infusion of alanine was given. On the day of dehydration an intravenous bolus injection of a loop diuretic (furosemide, 1 mg/kg) was superimposed. FHNC was calculated as the ratio between measured synthesis rates of urea nitrogen and blood alanine concentrations. Furosemide induced a weight loss of 1 kg. During dehydration, FHNC decreased by approx. 25% (41±11 to 54±10 litres/h; P < 0.02). On both occasions individual FHNC and glucagon values were positively correlated (r2 >0.6). In addition, dehydration more than halved the linear slope of the relationship (P < 0.05). The FHNC values were correlated with the urinary excretion of both potassium and sodium (r2 = 0.68, P < 0.01 and r2 = 0.62, P < 0.02 respectively). Changes in the reactivity of urea synthesis to glucagon (i.e. the ratio between FHNC and glucagon concentration) was negatively correlated with an indirectly estimated change in intracellular water (r2 = 0.79, P < 0.05). We conclude that acute moderate dehydration down-regulates both total urea synthesis and its sensitivity to glucagon. The latter was related to estimated intracellular water loss. Dehydration may thus have nitrogen-saving consequences with regard to the hepatic contribution to whole-body nitrogen homoeostasis. The mechanism of this effect and the relationship with sodium and potassium fluxes is not known." @default.
• W2024193334 created "2016-06-24" @default.
• W2024193334 creator A5060904410 @default.
• W2024193334 creator A5061620649 @default.
• W2024193334 creator A5080741438 @default.
• W2024193334 date "2001-09-04" @default.
• W2024193334 modified "2023-09-24" @default.
• W2024193334 title "Acute effects of moderate dehydration on the hepatic conversion of amino nitrogen into urea nitrogen in healthy men" @default.
• W2024193334 cites W147647363 @default.
• W2024193334 cites W1488357183 @default.
• W2024193334 cites W1816748024 @default.
• W2024193334 cites W1895615954 @default.
• W2024193334 cites W1973299781 @default.
• W2024193334 cites W1984254722 @default.
• W2024193334 cites W1985982956 @default.
• W2024193334 cites W2004190772 @default.
• W2024193334 cites W2007691946 @default.
• W2024193334 cites W2039681297 @default.
• W2024193334 cites W2044895159 @default.
• W2024193334 cites W2051142023 @default.
• W2024193334 cites W2054168709 @default.
• W2024193334 cites W2069114223 @default.
• W2024193334 cites W2078731699 @default.
• W2024193334 cites W2090380253 @default.
• W2024193334 cites W2139374484 @default.
• W2024193334 cites W2166389964 @default.
• W2024193334 cites W2332697941 @default.
• W2024193334 cites W2395312989 @default.
• W2024193334 cites W2435619490 @default.
• W2024193334 doi "https://doi.org/10.1042/cs1010339" @default.
• W2024193334 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11566069" @default.
• W2024193334 hasPublicationYear "2001" @default.
• W2024193334 type Work @default.
• W2024193334 sameAs 2024193334 @default.
• W2024193334 citedByCount "7" @default.
• W2024193334 countsByYear W20241933342013 @default.
• W2024193334 countsByYear W20241933342014 @default.
• W2024193334 countsByYear W20241933342015 @default.
• W2024193334 countsByYear W20241933342018 @default.
• W2024193334 countsByYear W20241933342020 @default.
• W2024193334 countsByYear W20241933342023 @default.
• W2024193334 crossrefType "journal-article" @default.
• W2024193334 hasAuthorship W2024193334A5060904410 @default.
• W2024193334 hasAuthorship W2024193334A5061620649 @default.
• W2024193334 hasAuthorship W2024193334A5080741438 @default.
• W2024193334 hasConcept C10146269 @default.
• W2024193334 hasConcept C126322002 @default.
• W2024193334 hasConcept C134018914 @default.
• W2024193334 hasConcept C178790620 @default.
• W2024193334 hasConcept C185592680 @default.
• W2024193334 hasConcept C2777955127 @default.
• W2024193334 hasConcept C2778563252 @default.
• W2024193334 hasConcept C2778769901 @default.
• W2024193334 hasConcept C2779918671 @default.
• W2024193334 hasConcept C2780365088 @default.
• W2024193334 hasConcept C537181965 @default.
• W2024193334 hasConcept C537208039 @default.
• W2024193334 hasConcept C55493867 @default.
• W2024193334 hasConcept C71315377 @default.
• W2024193334 hasConcept C71924100 @default.
• W2024193334 hasConcept C8101879 @default.
• W2024193334 hasConcept C86803240 @default.
• W2024193334 hasConceptScore W2024193334C10146269 @default.
• W2024193334 hasConceptScore W2024193334C126322002 @default.
• W2024193334 hasConceptScore W2024193334C134018914 @default.
• W2024193334 hasConceptScore W2024193334C178790620 @default.
• W2024193334 hasConceptScore W2024193334C185592680 @default.
• W2024193334 hasConceptScore W2024193334C2777955127 @default.
• W2024193334 hasConceptScore W2024193334C2778563252 @default.
• W2024193334 hasConceptScore W2024193334C2778769901 @default.
• W2024193334 hasConceptScore W2024193334C2779918671 @default.
• W2024193334 hasConceptScore W2024193334C2780365088 @default.
• W2024193334 hasConceptScore W2024193334C537181965 @default.
• W2024193334 hasConceptScore W2024193334C537208039 @default.
• W2024193334 hasConceptScore W2024193334C55493867 @default.
• W2024193334 hasConceptScore W2024193334C71315377 @default.
• W2024193334 hasConceptScore W2024193334C71924100 @default.
• W2024193334 hasConceptScore W2024193334C8101879 @default.
• W2024193334 hasConceptScore W2024193334C86803240 @default.
• W2024193334 hasIssue "4" @default.
• W2024193334 hasLocation W20241933341 @default.
• W2024193334 hasLocation W20241933342 @default.
• W2024193334 hasOpenAccess W2024193334 @default.
• W2024193334 hasPrimaryLocation W20241933341 @default.
• W2024193334 hasRelatedWork W112590946 @default.
• W2024193334 hasRelatedWork W1987027886 @default.
• W2024193334 hasRelatedWork W1993448409 @default.
• W2024193334 hasRelatedWork W1995192322 @default.
• W2024193334 hasRelatedWork W2024193334 @default.
• W2024193334 hasRelatedWork W2030896468 @default.
• W2024193334 hasRelatedWork W2033363128 @default.
• W2024193334 hasRelatedWork W2084888587 @default.
• W2024193334 hasRelatedWork W2086124255 @default.
• W2024193334 hasRelatedWork W2413511363 @default.
• W2024193334 hasVolume "101" @default.
• W2024193334 isParatext "false" @default.
• W2024193334 isRetracted "false" @default.
• W2024193334 magId "2024193334" @default.

• next