FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024194087> ?p ?o ?g. }

• W2024194087 endingPage "620" @default.
• W2024194087 startingPage "617" @default.
• W2024194087 abstract "Lipopolysaccharide (LPS)-stimulated macrophages produce large amounts of nitric oxide (NO) by inducible nitric oxide synthase (iNOS). This is an important mechanism in macrophage-induced septic shock and inflammation. In the present study, we tested a synthetic propenone compound, 1-furan-2-yl-3-pyridin-2-yl-propenone (FPP-3) for its ability to inhibit the production of tumor necrosis factor-alpha (TNF-alpha) and an inducible enzyme, iNOS, in the LPS-stimulated murine macrophage-like cell line, RAW264.7. FPP-3 consistently inhibited nitric oxide (NO) and TNF-alpha production in a dose dependent manner, with IC(50) values of 10.0 and 13.1 microM, respectively. Western blotting probed with specific anti-iNOS antibodies showed that the decrease in quantity of the NO product was accompanied by a decrease in the iNOS protein level. In cells transiently transfected with nuclear factor (NF)-kappaB promoter-luciferase reporter construct, this compound clearly inhibited the LPS-stimulated NF-kappaB activation. Moreover, this compound inhibited IkappaB-alpha degradation in a concentration and time-dependent manner. These results indicate that FPP-3 inhibits NO production via inhibition of degradation of IkappaB-alpha through NF-kappaB activation." @default.
• W2024194087 created "2016-06-24" @default.
• W2024194087 creator A5012424400 @default.
• W2024194087 creator A5033136222 @default.
• W2024194087 creator A5044451426 @default.
• W2024194087 creator A5048293219 @default.
• W2024194087 creator A5054143953 @default.
• W2024194087 creator A5054654340 @default.
• W2024194087 creator A5065444625 @default.
• W2024194087 creator A5067768440 @default.
• W2024194087 creator A5079374959 @default.
• W2024194087 date "2004-01-01" @default.
• W2024194087 modified "2023-10-05" @default.
• W2024194087 title "Inhibition of Nitric Oxide and Tumor Necrosis Factor-.ALPHA. (TNF-.ALPHA.) Production by Propenone Compound through Blockade of Nuclear Factor (NF)-.KAPPA.B Activation in Cultured Murine Macrophages" @default.
• W2024194087 cites W1496717884 @default.
• W2024194087 cites W1511086281 @default.
• W2024194087 cites W1560794427 @default.
• W2024194087 cites W1868478050 @default.
• W2024194087 cites W1977207335 @default.
• W2024194087 cites W2027152576 @default.
• W2024194087 cites W2031375858 @default.
• W2024194087 cites W2035988892 @default.
• W2024194087 cites W2092763906 @default.
• W2024194087 cites W2093816949 @default.
• W2024194087 cites W2114298357 @default.
• W2024194087 cites W2130282385 @default.
• W2024194087 cites W2131656392 @default.
• W2024194087 cites W2141685355 @default.
• W2024194087 cites W2142541950 @default.
• W2024194087 cites W4295677776 @default.
• W2024194087 doi "https://doi.org/10.1248/bpb.27.617" @default.
• W2024194087 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15133232" @default.
• W2024194087 hasPublicationYear "2004" @default.
• W2024194087 type Work @default.
• W2024194087 sameAs 2024194087 @default.
• W2024194087 citedByCount "63" @default.
• W2024194087 countsByYear W20241940872012 @default.
• W2024194087 countsByYear W20241940872013 @default.
• W2024194087 countsByYear W20241940872014 @default.
• W2024194087 countsByYear W20241940872015 @default.
• W2024194087 countsByYear W20241940872016 @default.
• W2024194087 countsByYear W20241940872017 @default.
• W2024194087 countsByYear W20241940872018 @default.
• W2024194087 countsByYear W20241940872019 @default.
• W2024194087 countsByYear W20241940872021 @default.
• W2024194087 countsByYear W20241940872022 @default.
• W2024194087 crossrefType "journal-article" @default.
• W2024194087 hasAuthorship W2024194087A5012424400 @default.
• W2024194087 hasAuthorship W2024194087A5033136222 @default.
• W2024194087 hasAuthorship W2024194087A5044451426 @default.
• W2024194087 hasAuthorship W2024194087A5048293219 @default.
• W2024194087 hasAuthorship W2024194087A5054143953 @default.
• W2024194087 hasAuthorship W2024194087A5054654340 @default.
• W2024194087 hasAuthorship W2024194087A5065444625 @default.
• W2024194087 hasAuthorship W2024194087A5067768440 @default.
• W2024194087 hasAuthorship W2024194087A5079374959 @default.
• W2024194087 hasBestOaLocation W20241940871 @default.
• W2024194087 hasConcept C104317684 @default.
• W2024194087 hasConcept C123298856 @default.
• W2024194087 hasConcept C134018914 @default.
• W2024194087 hasConcept C153911025 @default.
• W2024194087 hasConcept C178790620 @default.
• W2024194087 hasConcept C17991360 @default.
• W2024194087 hasConcept C185592680 @default.
• W2024194087 hasConcept C2777622882 @default.
• W2024194087 hasConcept C2778754761 @default.
• W2024194087 hasConcept C519581460 @default.
• W2024194087 hasConcept C54355233 @default.
• W2024194087 hasConcept C55493867 @default.
• W2024194087 hasConcept C81885089 @default.
• W2024194087 hasConcept C86339819 @default.
• W2024194087 hasConcept C86803240 @default.
• W2024194087 hasConcept C98274493 @default.
• W2024194087 hasConceptScore W2024194087C104317684 @default.
• W2024194087 hasConceptScore W2024194087C123298856 @default.
• W2024194087 hasConceptScore W2024194087C134018914 @default.
• W2024194087 hasConceptScore W2024194087C153911025 @default.
• W2024194087 hasConceptScore W2024194087C178790620 @default.
• W2024194087 hasConceptScore W2024194087C17991360 @default.
• W2024194087 hasConceptScore W2024194087C185592680 @default.
• W2024194087 hasConceptScore W2024194087C2777622882 @default.
• W2024194087 hasConceptScore W2024194087C2778754761 @default.
• W2024194087 hasConceptScore W2024194087C519581460 @default.
• W2024194087 hasConceptScore W2024194087C54355233 @default.
• W2024194087 hasConceptScore W2024194087C55493867 @default.
• W2024194087 hasConceptScore W2024194087C81885089 @default.
• W2024194087 hasConceptScore W2024194087C86339819 @default.
• W2024194087 hasConceptScore W2024194087C86803240 @default.
• W2024194087 hasConceptScore W2024194087C98274493 @default.
• W2024194087 hasIssue "5" @default.
• W2024194087 hasLocation W20241940871 @default.
• W2024194087 hasLocation W20241940872 @default.
• W2024194087 hasOpenAccess W2024194087 @default.
• W2024194087 hasPrimaryLocation W20241940871 @default.
• W2024194087 hasRelatedWork W196265488 @default.
• W2024194087 hasRelatedWork W1985900017 @default.
• W2024194087 hasRelatedWork W1986555336 @default.
• W2024194087 hasRelatedWork W1994072124 @default.

• next