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- W2024194760 abstract "Calponin is a family of actin-associated regulatory proteins that play a role in modulating smooth muscle contractility and actin cytoskeleton functions. The h2 isoform of calponin is found in smooth muscle and certain non-muscle cells. Keratinocytes, fibroblasts, and macrophages express h2-calponin at significant levels. To investigate the function of h2-calponin in these cell types that are key players in wound healing, we studied primary cultures of epidermal keratinocytes, dermal fibroblasts and peripheral macrophages isolated from h2-calponin knockout mice recently developed in our laboratory (Huang et al., J. Biol. Chem. 283:25887-99, 2008). Cell proliferation studies revealed faster growth rates of all of the three cell types from h2-calponin knockout mice as compared with that of wild type control cells. Similarly, the three types of cells exhibited faster migration in in vitro wound healing experiments when h2-calponin is absent. The results suggest that h2-calponin may be a regulatory factor in the balance of cell proliferation and migration during wound healing. We have previously observed that mechanical tension built in the cytoskeleton regulates h2-calponin expression and degradation in cells including keratinocytes and fibroblasts (Hossain et al., J. Biol. Chem. 280:42442-53, 2005; Biochemistry 45:15670-83, 2006). Therefore, experiments are underway to investigate the role of h2-calponin in the effect of mechanical tension on keratinocyte differentiation and skin wound healing." @default.
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- W2024194760 date "2009-02-01" @default.
- W2024194760 modified "2023-09-28" @default.
- W2024194760 title "Accelerated Proliferation and Migration of Keratinocytes, Fibroblasts and Macrophages Isolated from H2-Calponin Knockout Mice" @default.
- W2024194760 doi "https://doi.org/10.1016/j.bpj.2008.12.3319" @default.
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