FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024194906> ?p ?o ?g. }

• W2024194906 abstract "Abstract Background Duchenne muscular dystrophy (DMD) is characterized clinically by severe, progressive loss of skeletal muscle. The phenotype is much less severe in the mdx mouse model of DMD than that seen in patients with DMD. However, a “critical period” has been described for the mdx mouse, during which there is a peak in muscle weakness and degeneration/regeneration between the 2 nd and 5 th weeks of life. A number of studies have employed small animal magnetic resonance imaging (MRI) to examine skeletal muscle in various dystrophic models, but such studies represent a snapshot in time rather than a longitudinal view. Results The in vivo cross-sectional T 2 -weighted image of the healthy (wild type, WT) muscles is homogeneously dark and this homogeneity does not change with time, as there is no disease. We, and others, have shown marked changes in MRI in dystrophic muscle, with multiple, unevenly distributed focal hyperintensities throughout the bulk of the muscles. Here we monitored an mdx mouse using MRI from 5 to 80 weeks of age. Temporal MRI scans show an increase in heterogeneity shortly after the critical period, at 9 and 13 weeks of age, with a decrease in heterogeneity thereafter. The 4.3-fold increase in percent heterogeneity at week 9 and 13 is consistent with the notion of an early critical period described for mdx mice. Conclusions Age is a significant variable in quantitative MR studies of the mdx mouse. The mdx mouse is typically studied during the critical period, at a time that most closely mimics the DMD pathology, but the preliminary findings here, albeit based on imaging only one mdx mouse over time, suggest that the changes in MRI can occur shortly after this period, when the muscles are still recovering." @default.
• W2024194906 created "2016-06-24" @default.
• W2024194906 creator A5019721067 @default.
• W2024194906 creator A5079529198 @default.
• W2024194906 creator A5080669501 @default.
• W2024194906 creator A5083109409 @default.
• W2024194906 date "2013-07-09" @default.
• W2024194906 modified "2023-10-17" @default.
• W2024194906 title "Temporal changes in magnetic resonance imaging in the mdx mouse" @default.
• W2024194906 cites W1521447037 @default.
• W2024194906 cites W1965876184 @default.
• W2024194906 cites W1975205659 @default.
• W2024194906 cites W1975572872 @default.
• W2024194906 cites W1996425264 @default.
• W2024194906 cites W2012132915 @default.
• W2024194906 cites W2012182366 @default.
• W2024194906 cites W2014739354 @default.
• W2024194906 cites W2018483078 @default.
• W2024194906 cites W2025412356 @default.
• W2024194906 cites W2026231094 @default.
• W2024194906 cites W2034790803 @default.
• W2024194906 cites W2050289652 @default.
• W2024194906 cites W2056637341 @default.
• W2024194906 cites W2059783344 @default.
• W2024194906 cites W2066180106 @default.
• W2024194906 cites W2069908769 @default.
• W2024194906 cites W2070936696 @default.
• W2024194906 cites W2072336811 @default.
• W2024194906 cites W2073484726 @default.
• W2024194906 cites W2076738615 @default.
• W2024194906 cites W2094304792 @default.
• W2024194906 cites W2121974849 @default.
• W2024194906 cites W2137714739 @default.
• W2024194906 cites W2137848437 @default.
• W2024194906 cites W2139774727 @default.
• W2024194906 cites W2140180794 @default.
• W2024194906 cites W2158835728 @default.
• W2024194906 cites W2171324004 @default.
• W2024194906 cites W4255617529 @default.
• W2024194906 doi "https://doi.org/10.1186/1756-0500-6-262" @default.
• W2024194906 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3716616" @default.
• W2024194906 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23837666" @default.
• W2024194906 hasPublicationYear "2013" @default.
• W2024194906 type Work @default.
• W2024194906 sameAs 2024194906 @default.
• W2024194906 citedByCount "22" @default.
• W2024194906 countsByYear W20241949062014 @default.
• W2024194906 countsByYear W20241949062015 @default.
• W2024194906 countsByYear W20241949062016 @default.
• W2024194906 countsByYear W20241949062017 @default.
• W2024194906 countsByYear W20241949062018 @default.
• W2024194906 countsByYear W20241949062020 @default.
• W2024194906 countsByYear W20241949062021 @default.
• W2024194906 crossrefType "journal-article" @default.
• W2024194906 hasAuthorship W2024194906A5019721067 @default.
• W2024194906 hasAuthorship W2024194906A5079529198 @default.
• W2024194906 hasAuthorship W2024194906A5080669501 @default.
• W2024194906 hasAuthorship W2024194906A5083109409 @default.
• W2024194906 hasBestOaLocation W20241949061 @default.
• W2024194906 hasConcept C126322002 @default.
• W2024194906 hasConcept C126838900 @default.
• W2024194906 hasConcept C142724271 @default.
• W2024194906 hasConcept C143409427 @default.
• W2024194906 hasConcept C146638467 @default.
• W2024194906 hasConcept C150903083 @default.
• W2024194906 hasConcept C207001950 @default.
• W2024194906 hasConcept C2778750056 @default.
• W2024194906 hasConcept C2778943923 @default.
• W2024194906 hasConcept C2779030066 @default.
• W2024194906 hasConcept C2779959927 @default.
• W2024194906 hasConcept C2780394045 @default.
• W2024194906 hasConcept C71924100 @default.
• W2024194906 hasConcept C86803240 @default.
• W2024194906 hasConceptScore W2024194906C126322002 @default.
• W2024194906 hasConceptScore W2024194906C126838900 @default.
• W2024194906 hasConceptScore W2024194906C142724271 @default.
• W2024194906 hasConceptScore W2024194906C143409427 @default.
• W2024194906 hasConceptScore W2024194906C146638467 @default.
• W2024194906 hasConceptScore W2024194906C150903083 @default.
• W2024194906 hasConceptScore W2024194906C207001950 @default.
• W2024194906 hasConceptScore W2024194906C2778750056 @default.
• W2024194906 hasConceptScore W2024194906C2778943923 @default.
• W2024194906 hasConceptScore W2024194906C2779030066 @default.
• W2024194906 hasConceptScore W2024194906C2779959927 @default.
• W2024194906 hasConceptScore W2024194906C2780394045 @default.
• W2024194906 hasConceptScore W2024194906C71924100 @default.
• W2024194906 hasConceptScore W2024194906C86803240 @default.
• W2024194906 hasIssue "1" @default.
• W2024194906 hasLocation W20241949061 @default.
• W2024194906 hasLocation W20241949062 @default.
• W2024194906 hasLocation W20241949063 @default.
• W2024194906 hasLocation W20241949064 @default.
• W2024194906 hasOpenAccess W2024194906 @default.
• W2024194906 hasPrimaryLocation W20241949061 @default.
• W2024194906 hasRelatedWork W1521447037 @default.
• W2024194906 hasRelatedWork W197168872 @default.
• W2024194906 hasRelatedWork W1978126627 @default.
• W2024194906 hasRelatedWork W2034387481 @default.
• W2024194906 hasRelatedWork W2044981533 @default.
• W2024194906 hasRelatedWork W2069165474 @default.

• next