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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024195722> ?p ?o ?g. }

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• W2024195722 abstract "A new series of potent 8-hydroxyquinolines was designed based on the newly resolved X-ray crystal structure of EGLN-1. Both alkyl and aryl 8-hydroxyquinoline-7-carboxyamides were good HIF-1α prolyl hydroxylase (EGLN) inhibitors. In subsequent VEGF induction assays, these exhibited potent VEGF activity. In addition, this class of compounds did show the ability to stabilize HIF-1α." @default.
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• W2024195722 date "2006-11-01" @default.
• W2024195722 modified "2023-10-15" @default.
• W2024195722 title "Structure-based design, synthesis, and SAR evaluation of a new series of 8-hydroxyquinolines as HIF-1α prolyl hydroxylase inhibitors" @default.
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• W2024195722 doi "https://doi.org/10.1016/j.bmcl.2006.08.040" @default.
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