Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024200878> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W2024200878 endingPage "484" @default.
- W2024200878 startingPage "478" @default.
- W2024200878 abstract "Gemifloxacin is a novel fluoroquinolone, currently in development for the treatment of respiratory tract infections. This double-blind (with respect to gemifloxacin), randomized, crossover study investigated the possibility of pharmacokinetic interaction between gemifloxacin and theophylline. After a 4–8-day run-in phase to establish the dose of theophylline required to achieve a trough plasma concentration range of 8–15 mg/l, 15 healthy volunteers entered a randomized treatment phase. Volunteers then received oral theophylline, 300–400 mg twice daily, for 22 days. On days 5–11 and 16–22, they also received either placebo or gemifloxacin, 320 mg p.o. once daily, in a crossover fashion. Blood samples were collected up to 12 h after the morning dose of theophylline on days 11 and 22. Theophylline pharmacokinetics were not affected by the co-administration of gemifloxacin. The maximum plasma concentration (C<sub>max</sub>) for theophylline ranged from 8.12 to 17.71 mg/l and from 8.79 to 16.35 mg/l during concomitant administration with gemifloxacin and placebo, respectively. The corresponding ranges of the area under the plasma concentration-time curve from time zero to the last quantifiable plasma concentration (AUC<sub>(0–12)</sub>) were 84.6–177.5 mg·h/l and 94.8–165.1 mg·h/l during gemifloxacin and placebo administration, respectively. The point estimates (90% confidence intervals) for dose-normalized AUC<sub>(0–12)</sub> and C<sub>max</sub> (theophylline + gemifloxacin):(theophylline + placebo) were 0.99 (0.93, 1.05) and 1.02 (0.93, 1.11), respectively, which were entirely within the equivalence range (0.80, 1.25). The co-administration of gemifloxacin and theophylline was well tolerated, with no clinically significant changes seen in vital signs, 12-lead electrocardiogram readings or laboratory parameters. Adverse events were generally transient, mild to moderate in nature and similar during the gemifloxacin and placebo treatment periods. In conclusion, theophylline and gemifloxacin may be co-administered without any adjustment in theophylline dose." @default.
- W2024200878 created "2016-06-24" @default.
- W2024200878 creator A5003153077 @default.
- W2024200878 creator A5027799938 @default.
- W2024200878 creator A5031680188 @default.
- W2024200878 creator A5053401820 @default.
- W2024200878 creator A5062962313 @default.
- W2024200878 date "1999-01-01" @default.
- W2024200878 modified "2023-10-14" @default.
- W2024200878 title "Lack of Effect of Gemifloxacin on the Steady-State Pharmacokinetics of Theophylline in Healthy Volunteers" @default.
- W2024200878 cites W4248455835 @default.
- W2024200878 doi "https://doi.org/10.1159/000007241" @default.
- W2024200878 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10567778" @default.
- W2024200878 hasPublicationYear "1999" @default.
- W2024200878 type Work @default.
- W2024200878 sameAs 2024200878 @default.
- W2024200878 citedByCount "19" @default.
- W2024200878 countsByYear W20242008782014 @default.
- W2024200878 countsByYear W20242008782018 @default.
- W2024200878 crossrefType "journal-article" @default.
- W2024200878 hasAuthorship W2024200878A5003153077 @default.
- W2024200878 hasAuthorship W2024200878A5027799938 @default.
- W2024200878 hasAuthorship W2024200878A5031680188 @default.
- W2024200878 hasAuthorship W2024200878A5053401820 @default.
- W2024200878 hasAuthorship W2024200878A5062962313 @default.
- W2024200878 hasConcept C112705442 @default.
- W2024200878 hasConcept C126322002 @default.
- W2024200878 hasConcept C142724271 @default.
- W2024200878 hasConcept C185592680 @default.
- W2024200878 hasConcept C204787440 @default.
- W2024200878 hasConcept C27081682 @default.
- W2024200878 hasConcept C2776042228 @default.
- W2024200878 hasConcept C2776088887 @default.
- W2024200878 hasConcept C2777056448 @default.
- W2024200878 hasConcept C2778095195 @default.
- W2024200878 hasConcept C2781018748 @default.
- W2024200878 hasConcept C3019249092 @default.
- W2024200878 hasConcept C501593827 @default.
- W2024200878 hasConcept C55493867 @default.
- W2024200878 hasConcept C71924100 @default.
- W2024200878 hasConcept C76318530 @default.
- W2024200878 hasConcept C87813604 @default.
- W2024200878 hasConcept C98274493 @default.
- W2024200878 hasConceptScore W2024200878C112705442 @default.
- W2024200878 hasConceptScore W2024200878C126322002 @default.
- W2024200878 hasConceptScore W2024200878C142724271 @default.
- W2024200878 hasConceptScore W2024200878C185592680 @default.
- W2024200878 hasConceptScore W2024200878C204787440 @default.
- W2024200878 hasConceptScore W2024200878C27081682 @default.
- W2024200878 hasConceptScore W2024200878C2776042228 @default.
- W2024200878 hasConceptScore W2024200878C2776088887 @default.
- W2024200878 hasConceptScore W2024200878C2777056448 @default.
- W2024200878 hasConceptScore W2024200878C2778095195 @default.
- W2024200878 hasConceptScore W2024200878C2781018748 @default.
- W2024200878 hasConceptScore W2024200878C3019249092 @default.
- W2024200878 hasConceptScore W2024200878C501593827 @default.
- W2024200878 hasConceptScore W2024200878C55493867 @default.
- W2024200878 hasConceptScore W2024200878C71924100 @default.
- W2024200878 hasConceptScore W2024200878C76318530 @default.
- W2024200878 hasConceptScore W2024200878C87813604 @default.
- W2024200878 hasConceptScore W2024200878C98274493 @default.
- W2024200878 hasIssue "6" @default.
- W2024200878 hasLocation W20242008781 @default.
- W2024200878 hasLocation W20242008782 @default.
- W2024200878 hasOpenAccess W2024200878 @default.
- W2024200878 hasPrimaryLocation W20242008781 @default.
- W2024200878 hasRelatedWork W1506756164 @default.
- W2024200878 hasRelatedWork W1976194241 @default.
- W2024200878 hasRelatedWork W2019391076 @default.
- W2024200878 hasRelatedWork W2020044383 @default.
- W2024200878 hasRelatedWork W2022017451 @default.
- W2024200878 hasRelatedWork W2024200878 @default.
- W2024200878 hasRelatedWork W2029624093 @default.
- W2024200878 hasRelatedWork W2034663435 @default.
- W2024200878 hasRelatedWork W2072870423 @default.
- W2024200878 hasRelatedWork W2169879913 @default.
- W2024200878 hasVolume "45" @default.
- W2024200878 isParatext "false" @default.
- W2024200878 isRetracted "false" @default.
- W2024200878 magId "2024200878" @default.
- W2024200878 workType "article" @default.