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• W2024202014 startingPage "1498" @default.
• W2024202014 abstract "To assess the yield of interictal EEG spiking in standard and whole-night sleep EEGs in elderly subjects with recent-onset focal seizures compared to younger patients. Detection of interictal epileptiform abnormalities (IEAs) and rating of mean spike index (number of interictal discharges/minute) values for different sleep stages (NREM stages 1–2 and 3–4 and REM sleep) in standard EEG (S-EEG) and 24-h ambulatory EEG (A-EEG) at first referral in three groups of thirty consecutive outpatients [aged 20–39 (young), 40–59 (adults) and ⩾60 years (elderly)], retrospectively selected according to a subsequent diagnosis of focal epilepsy of unknown cause, no sleep disorders or drugs or comorbidities affecting sleep and EEG. Elderly subjects showed a lower rate of IEAs on S-EEG (p < 0.01) but a higher propensity for spiking during deep NREM sleep, 11/30 showing IEAs exclusively during stages 3–4. Mean spike index showed a significant increase in IEAs between sleep stages 1–2 and 3–4 in the elderly subjects (p < 0.001). A significant association emerged between IEAs during deep sleep and age (p < 0.001). EEG recordings covering deep NREM sleep should be recommended when IEAs detection is needed to support a diagnosis of epilepsy in elderly subjects." @default.
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• W2024202014 date "2015-08-01" @default.
• W2024202014 modified "2023-10-17" @default.
• W2024202014 title "Interictal spiking in adult newly-diagnosed focal epilepsy of unknown cause: The effect of age" @default.
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• W2024202014 doi "https://doi.org/10.1016/j.clinph.2014.10.155" @default.
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